Shin Da Young, Park Chan Kee, Jung Kyoung In, Park Hae Young Lopilly, Lee Na Young
Department of Ophthalmology, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
Department of Ophthalmology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
J Clin Med. 2023 Feb 17;12(4):1593. doi: 10.3390/jcm12041593.
To investigate the characteristics of normotensive glaucoma (NTG) in the fellow eye of patients with unilateral pseudoexfoliation syndrome (PXS).
This study is a retrospective chart review. We included 313 patients with NTG. Using the 1:1 matched propensity score, only 94 well-matched patients were selected. A total of 47 NTG patients who had PXS in their contralateral eye (PXS group) and 47 NTG patients who did not (control group) were compared. The propensity score was matched based on age, mean intraocular pressure (IOP), baseline retinal nerve fiber layer (RNFL) thickness and baseline mean deviation (MD) of visual field (VF) score. The diagnosis of NTG was based on the presence of glaucomatous optic nerve head injury with VF defect, intraocular pressure less than 22 mmHg, open angles and no pseudoexfoliation material.
The PXS group had a higher ratio of males (34.0%) than the control group (17.0%). No significant differences were observed between the two groups in terms of CCT, axial length, untreated baseline IOP, baseline PSD of VF, systemic blood pressure and follow-up duration. The rate of RNFL thinning was significantly faster in the PXS group (-1.88 ± 2.83 μm/year) compared with the control group (-0.27 ± 5.29 μm/year) ( = 0.02). The progression rate of VF MD was slightly faster in PXS than in the control group, but there was no statistically significant difference (PXS group, -0.33 ± 0.90 dB/year; control group, -0.11 ± 0.84 dB/year; = 0.236).
NTG eyes with PXS showed faster RNFL thinning than did control NTG eyes.
研究单侧假性剥脱综合征（PXS）患者对侧眼中正常眼压性青光眼（NTG）的特征。
本研究为回顾性病历审查。我们纳入了313例NTG患者。使用1:1匹配倾向评分，仅选择了94例匹配良好的患者。比较了47例对侧眼患有PXS的NTG患者（PXS组）和47例对侧眼未患PXS的NTG患者（对照组）。倾向评分根据年龄、平均眼压（IOP）、基线视网膜神经纤维层（RNFL）厚度和视野（VF）评分的基线平均偏差（MD）进行匹配。NTG的诊断基于存在青光眼性视神经乳头损伤伴VF缺损、眼压低于22 mmHg、房角开放且无假性剥脱物质。
PXS组男性比例（34.0%）高于对照组（17.0%）。两组在中央角膜厚度（CCT）、眼轴长度、未治疗的基线眼压、VF的基线模式标准差（PSD）、全身血压和随访时间方面未观察到显著差异。与对照组（-0.27±5.29μm/年）相比，PXS组RNFL变薄率显著更快（-1.88±2.83μm/年）（P = 0.02）。PXS组VF MD的进展率略快于对照组，但无统计学显著差异（PXS组，-0.33±0.90 dB/年；对照组，-0.11±0.84 dB/年；P = 0.236）。
患有PXS的NTG眼比对照NTG眼表现出更快的RNFL变薄。
