Lee Jong Yeon, Hwang Young Hoon, Lee Sun Min, Kim Yong Yeon
Department of Ophthalmology, Gachon University Gil Hospital, Incheon, Korea.
Korean J Ophthalmol. 2012 Jun;26(3):163-8. doi: 10.3341/kjo.2012.26.3.163. Epub 2012 May 22.
To evaluate the association between age and peripapillary retinal nerve fiber layer (RNFL) thickness measured by Cirrus high-definition (HD) spectral domain optical coherence tomography (OCT) in healthy Korean subjects.
A total of 302 eyes from 155 healthy Korean subjects (age range, 20 to 79 years) underwent RNFL thickness measurements using the Cirrus HD-OCT. Average, quadrant, and clock-hour RNFL thickness parameters were analyzed in terms of age using linear mixed effect models.
Average RNFL demonstrated a slope of -2.1 µm per decade of age (p < 0.001). In quadrant analysis, superior (-3.4 µm/decade, p < 0.001) and inferior (-2.9 µm/decade, p < 0.001) quadrants showed steeper slopes, whereas temporal (-1.1 µm/decade, p < 0.001) and nasal (-1.0 µm/decade, p < 0.001) quadrants revealed shallower slopes. Among the 12 clock-hour sectors, clock hours 6 (-4.5 µm/decade, p < 0.001) and 1 (-4.1 µm/decade, p < 0.001) showed the greatest tendency to decline with age; RNFLs of the 3 (-0.2 µm/decade, p = 0.391) and 4 (-0.6 µm/decade, p = 0.052) o'clock hour sectors did not show significant decay.
RNFL thickness was associated with age, especially in superior and inferior areas. The topographic distribution of correlation between age and RNFL thickness was not uniform.
评估在健康韩国受试者中，年龄与通过Cirrus高清（HD）光谱域光学相干断层扫描（OCT）测量的视乳头周围视网膜神经纤维层（RNFL）厚度之间的关联。
对155名健康韩国受试者（年龄范围20至79岁）的302只眼睛使用Cirrus HD-OCT进行RNFL厚度测量。使用线性混合效应模型，根据年龄分析平均、象限和钟点RNFL厚度参数。
平均RNFL显示每十年年龄下降2.1 µm的斜率（p < 0.001）。在象限分析中，上方（-3.4 µm/十年，p < 0.001）和下方（-2.9 µm/十年，p < 0.001）象限显示出更陡的斜率，而颞侧（-1.1 µm/十年，p < 0.001）和鼻侧（-1.0 µm/十年，p < 0.001）象限斜率较平缓。在12个钟点扇形区域中，6点（-4.5 µm/十年，p < 0.001）和1点（-4.1 µm/十年，p < 0.001）扇形区域随年龄下降的趋势最明显；3点（-0.2 µm/十年，p = 0.391）和4点（-0.6 µm/十年，p = 0.052）扇形区域的RNFL没有显示出明显衰减。
RNFL厚度与年龄相关，尤其是在上方和下方区域。年龄与RNFL厚度之间相关性的地形分布并不均匀。
