Chemical Investigation of Endophytic YSP3 Reveals New Antibacterial and Cytotoxic Agents.

Chemical investigation of the plant-derived endophytic fungus YSP3 led to the isolation of four new compounds (-), including two new xanthones (phomopthane A and B, and ), one new alternariol methyl ether derivative () and one α-pyrone derivative (phomopyrone B, ), together with eight known compounds (-). The structures of new compounds were interpreted on the basis of spectroscopic data and single-crystal X-ray diffraction analysis. All new compounds were assessed for their antimicrobial and cytotoxic potential. Compound showed cytotoxic activity against HeLa and MCF-7 cells with IC values of 5.92 µM and 7.50 µM, respectively, while compound has an antibacterial effect on (MIC value 16 μg/mL).