内生真菌 Microdiplodia sp. WGHS5 的半日花烷倍半萜和苯衍生物。
Eremophilane Sesquiterpenes and Benzene Derivatives from the Endophyte Microdiplodia sp. WGHS5.
机构信息
College of Plant Protection, State and Local Joint Engineering Research Center of Green Pesticide Invention and Application, Nanjing Agricultural University, Nanjing, 210095, P. R. China.
Key Laboratory of Integrated Management of Crop Diseases and Pests, Ministry of Education, Nanjing, 210095, P. R. China.
出版信息
Chem Biodivers. 2021 Apr;18(4):e2000949. doi: 10.1002/cbdv.202000949. Epub 2021 Mar 19.
Three new eremophilane sesquiterpenes phomadecalins G-I (1-3) and two new benzene derivatives microdiplzenes A and B (12 and 13), together with nine known eremophilane sesquiterpenes (4-11 and 14) were isolated from an endophytic fungus, Microdiplodia sp. WGHS5. Their structures were elucidated by the interpretation of HR-ESI-MS and NMR data; meanwhile, the absolute configurations of new compounds were determined on the base of ECD calculations. All compounds were evaluated for the antimicrobial activities and antiproliferative effect on human gastric cancer cell lines (BGC-823).
从内生真菌 Microdiplodia sp. WGHS5 中分离得到了三个新的半日花烷倍半萜 phomadecalins G-I（1-3）和两个新的苯衍生物 microdiplzenes A 和 B（12 和 13），以及九个已知的半日花烷倍半萜（4-11 和 14）。通过 HR-ESI-MS 和 NMR 数据分析阐明了它们的结构；同时，根据 ECD 计算确定了新化合物的绝对构型。所有化合物均进行了抗微生物活性和对人胃癌细胞系 BGC-823 的抗增殖作用评估。
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