二孢菌素A - C：来自内生真菌BZM - 15的三种新代谢产物。
Diaportones A-C: Three New Metabolites From Endophytic Fungus BZM-15.
作者信息
Kang Fenghua, Lu Xiuxiang, Zhang Sha, Chen Dekun, Kuang Min, Peng Weiwei, Tan Jianbing, Xu Kangping, Zou Zhenxing, Tan Haibo
机构信息
Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China.
Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Central South University, Changsha, China.
出版信息
Front Chem. 2021 Nov 19;9:755351. doi: 10.3389/fchem.2021.755351. eCollection 2021.
Phytochemical investigation of BZM-15 led to one new -butyrolactone derivative, diaportone A (), one cyclopentenone derivative, diaportone B (), and one monoterpene derivative, diaportone C (), along with six known compounds (, , and ). Their structures as well as the absolute configurations were characterized by means of NMR, HRESIMS, and ECD spectroscopy and quantum chemistry calculation, respectively. Furthermore, all compounds were evaluated for their cytotoxic activity and antibacterial activity, and compounds and displayed significant antiproliferative effects on three human cancer cell lines (SF-268, MCF-7, and HepG2) with IC values ranging from 3.6 to 15.8 μM.
对BZM - 15进行植物化学研究，得到了一种新的γ-丁内酯衍生物——二孢菌素A（）、一种环戊烯酮衍生物——二孢菌素B（）和一种单萜衍生物——二孢菌素C（），以及六种已知化合物（、和）。它们的结构以及绝对构型分别通过核磁共振（NMR）、高分辨电喷雾电离质谱（HRESIMS）、电子圆二色谱（ECD）光谱和量子化学计算进行了表征。此外，对所有化合物的细胞毒性活性和抗菌活性进行了评估，化合物和对三种人类癌细胞系（SF - 268、MCF - 7和HepG2）显示出显著的抗增殖作用，IC值范围为3.6至15.8 μM。
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