Romanowska-Dixon Bożena, Dębicka-Kumela Magdalena, Śmigielski Janusz, Nowak Michał Szymon
Department of Ophthalmology and Ophthalmic Oncology, Jagiellonian University Collegium Medicum, 38 Kopernika Str., 31-501 Krakow, Poland.
Department of Statistics, State University of Applied Science in Konin, 1 Przyjazni Str., 65-510 Konin, Poland.
J Pers Med. 2023 Feb 17;13(2):353. doi: 10.3390/jpm13020353.
(1) Background: The aim of this study was to analyze the sex differences in the treatment of uveal melanoma (UM) in a group of 1336 patients from a national referral center during the period 2018-2021. (2) Materials and Methods: The study was designed in a retrospective manner. A total of 1336 patients who were newly diagnosed with UM at the Department of Ophthalmology and Ophthalmic Oncology, Jagiellonian University Collegium Medicum, Krakow, Poland, between 1 January 2018 and 31 December 2021, were included in the study. The demographic and clinical data were compiled, including the sex of patients and the treatment methods. (3) Results: In total, 1336 patients with ocular melanoma were identified, including 726 women (54.34%) and 610 men (45.66%). A total of 49.70% of tumors were localized in the right eye and 50.30% in the left eye. UMs were localized statistically significantly more frequently posterior to the equator of the eye globe in men than in women (79.67% vs. 74.10%, Chi^2 Pearson test = 0.035). Tumors tended to be larger in men, but this difference was not clinically significant. Men were enucleated more often than women (23.44% vs. 18.04%, Chi^2 Pearson test = 0.015). (4) Conclusions: Statistically significant sex differences were found in the treatment of uveal melanoma in a national referral center in Poland, with men being enucleated more often than women.
(1) 背景：本研究旨在分析2018年至2021年期间，来自一家国家转诊中心的1336例葡萄膜黑色素瘤（UM）患者治疗中的性别差异。(2) 材料与方法：本研究采用回顾性设计。纳入了2018年1月1日至2021年12月31日期间在波兰克拉科夫雅盖隆大学医学院眼科和眼科肿瘤学系新诊断为UM的1336例患者。收集了人口统计学和临床数据，包括患者性别和治疗方法。(3) 结果：共识别出1336例眼黑色素瘤患者，其中女性726例（54.34%），男性610例（45.66%）。共有49.70%的肿瘤位于右眼，50.30%位于左眼。男性UM位于眼球赤道后方的比例在统计学上显著高于女性（79.67%对74.10%，Pearson卡方检验 = 0.035）。男性的肿瘤往往更大，但这种差异无临床意义。男性眼球摘除术的比例高于女性（23.44%对18.04%，Pearson卡方检验 = 0.015）。(4) 结论：在波兰一家国家转诊中心的葡萄膜黑色素瘤治疗中发现了具有统计学意义的性别差异，男性眼球摘除术的比例高于女性。
