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姜黄素治疗炎症性肠病的作用及机制综述

Review of the Effects and Mechanism of Curcumin in the Treatment of Inflammatory Bowel Disease.

作者信息

Lin Yuan, Liu Hengjian, Bu Lingling, Chen Chen, Ye Xiaofeng

机构信息

Changzhou Hospital of Traditional Chinese Medicine, Changzhou, China.

出版信息

Front Pharmacol. 2022 Jun 20;13:908077. doi: 10.3389/fphar.2022.908077. eCollection 2022.

Abstract

Curcumin is extracted from the rhizomes of . It is now widely used in food processing, cosmetics, dyes, etc. Current researching indicates that curcumin has high medical value, including anti-inflammatory, antioxidant, anti-tumor, anti-apoptotic, anti-fibrosis, immune regulation and other effects, and can be used to treat a variety of diseases. Inflammatory bowel disease (IBD) is a nonspecific inflammatory disease of the intestine including Crohn's disease (CD) and ulcerative colitis (UC). The drug treatment effect is often limited and accompanied by side effects. A large number of basic and clinical studies have shown that curcumin has the effect of treating IBD and also can maintain the remission of IBD. In this review, the research of curcumin on IBD in recent years is summarized in order to provide reference for further research and application of curcumin.

摘要

姜黄素是从姜黄根茎中提取的。它目前广泛应用于食品加工、化妆品、染料等领域。目前的研究表明,姜黄素具有很高的医学价值,包括抗炎、抗氧化、抗肿瘤、抗凋亡、抗纤维化、免疫调节等作用,可用于治疗多种疾病。炎症性肠病(IBD)是一种肠道非特异性炎症性疾病,包括克罗恩病(CD)和溃疡性结肠炎(UC)。药物治疗效果往往有限且伴有副作用。大量基础和临床研究表明,姜黄素具有治疗IBD的作用,还能维持IBD的缓解。在这篇综述中,总结了近年来姜黄素对IBD的研究,以便为姜黄素的进一步研究和应用提供参考。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80f0/9250976/e9cc8dded739/fphar-13-908077-g001.jpg

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