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一种γ-氨基丁酸受体调节剂和利用挥发物组学作为慢性暴露于氟虫腈的候选标志物所证实的信息素化合物 。 （原文句子不完整，翻译可能不太准确，你可补充完整原文以便更准确翻译）

A GABA Receptor Modulator and Semiochemical Compounds Evidenced Using Volatolomics as Candidate Markers of Chronic Exposure to Fipronil in .

作者信息

Fernandes Vincent, Hidalgo Kevin, Diogon Marie, Mercier Frédéric, Angénieux Magaly, Ratel Jérémy, Delbac Frédéric, Engel Erwan, Bouchard Philippe

机构信息

CNRS, UMR6023, Laboratoire Microorganismes Génome et Environnement, Université Clermont Auvergne, F-63000 Clermont-Ferrand, France.

INRAE, UR370 Qualité des Produites Animaux, MASS Group, F-63122 Saint-Genès-Champanelle, France.

出版信息

Metabolites. 2023 Jan 26;13(2):185. doi: 10.3390/metabo13020185.

DOI:10.3390/metabo13020185
PMID:36837804
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9959115/
Abstract

Among the various "omics" approaches that can be used in toxicology, volatolomics is in full development. A volatolomic study was carried out on soil bacteria to validate the proof of concept, and this approach was implemented in a new model organism: the honeybee . Emerging bees raised in the laboratory in pain-type cages were used. Volatolomics analysis was performed on cuticles, fat bodies, and adhering tissues (abdomens without the digestive tract), after 14 and 21 days of chronic exposure to 0.5 and 1 µg/L of fipronil, corresponding to sublethal doses. The VOCs analysis was processed using an HS-SPME/GC-MS method. A total of 281 features were extracted and tentatively identified. No significant effect of fipronil on the volatolome could be observed after 14 days of chronic exposure. Mainly after 21 days of exposure, a volatolome deviation appeared. The study of this deviation highlighted 11 VOCs whose signal abundances evolved during the experiment. Interestingly, the volatolomics approach revealed a VOC (2,6-dimethylcyclohexanol) that could act on GABA receptor activity (the fipronil target) and VOCs associated with semiochemical activities (pheromones, repellent agents, and compounds related to the Nasonov gland) leading to a potential impact on bee behavior.

摘要

在毒理学中可采用的各种“组学”方法中，挥发性有机化合物组学（挥发组学）正处于全面发展阶段。针对土壤细菌开展了一项挥发组学研究以验证概念证明，并且该方法在一种新的模式生物——蜜蜂中得以应用。使用在实验室中饲养于疼痛型笼中的新羽化蜜蜂。在对0.5和1微克/升氟虫腈进行14天和21天的慢性暴露（对应亚致死剂量）后，对表皮、脂肪体和附着组织（不含消化道的腹部）进行挥发组学分析。挥发性有机化合物（VOC）分析采用顶空固相微萃取/气相色谱 - 质谱法进行。共提取并初步鉴定了281个特征峰。慢性暴露14天后未观察到氟虫腈对挥发组有显著影响。主要在暴露21天后，出现了挥发组偏差。对这种偏差的研究突出了11种挥发性有机化合物，其信号丰度在实验过程中发生了变化。有趣的是，挥发组学方法揭示了一种可能作用于GABA受体活性（氟虫腈的作用靶点）的挥发性有机化合物（2,6 - 二甲基环己醇）以及与化学生态活性相关的挥发性有机化合物（信息素、驱避剂和与纳氏腺相关的化合物），这可能对蜜蜂行为产生潜在影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a14/9959115/c140f018415c/metabolites-13-00185-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a14/9959115/e26d5ac2f3d7/metabolites-13-00185-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a14/9959115/9c402b0342e7/metabolites-13-00185-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a14/9959115/cd5dc168f3d4/metabolites-13-00185-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a14/9959115/55fa779f00cf/metabolites-13-00185-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a14/9959115/fa5a4626dab9/metabolites-13-00185-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a14/9959115/11917b706447/metabolites-13-00185-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a14/9959115/c140f018415c/metabolites-13-00185-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a14/9959115/e26d5ac2f3d7/metabolites-13-00185-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a14/9959115/9c402b0342e7/metabolites-13-00185-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a14/9959115/cd5dc168f3d4/metabolites-13-00185-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a14/9959115/55fa779f00cf/metabolites-13-00185-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a14/9959115/fa5a4626dab9/metabolites-13-00185-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a14/9959115/11917b706447/metabolites-13-00185-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a14/9959115/c140f018415c/metabolites-13-00185-g007.jpg

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The Honeybee Gut Microbiota Is Altered after Chronic Exposure to Different Families of Insecticides and Infection by Nosema ceranae.慢性接触不同种类杀虫剂和感染蜂囊菌后，蜜蜂肠道微生物组发生改变。
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Volatolomics in Bacterial Ecotoxicology, A Novel Method for Detecting Signatures of Pesticide Exposure?
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