Laurindo Lucas Fornari, de Maio Mariana Canevari, Minniti Giulia, de Góes Corrêa Natália, Barbalho Sandra Maria, Quesada Karina, Guiguer Elen Landgraf, Sloan Kátia Portero, Detregiachi Claudia R P, Araújo Adriano Cressoni, de Alvares Goulart Ricardo
Department of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), Avenida Hygino Muzzy Filho, 1001, Marília 17525-902, São Paulo, Brazil.
Department of Biochemistry and Pharmacology, School of Medicine, Faculdade de Medicina de Marília (FAMEMA), Avenida Monte Carmelo, 800, Marília 17519-030, São Paulo, Brazil.
Metabolites. 2023 Feb 7;13(2):243. doi: 10.3390/metabo13020243.
Inflammatory bowel diseases (IBDs) are related to nuclear factor erythroid 2-related factor 2 (Nrf2) dysregulation. In vitro and in vivo studies using phytocompounds as modulators of the Nrf2 signaling in IBD have already been published. However, no existing review emphasizes the whole scenario for the potential of plants and phytocompounds as regulators of Nrf2 in IBD models and colitis-associated colorectal carcinogenesis. For these reasons, this study aimed to build a review that could fill this void. The PubMed, EMBASE, COCHRANE, and Google Scholar databases were searched. The literature review showed that medicinal plants and phytochemicals regulated the Nrf2 on IBD and IBD-associated colorectal cancer by amplifying the expression of the Nrf2-mediated phase II detoxifying enzymes and diminishing NF-κB-related inflammation. These effects improve the bowel environment, mucosal barrier, colon, and crypt disruption, reduce ulceration and microbial translocation, and consequently, reduce the disease activity index (DAI). Moreover, the modulation of Nrf2 can regulate various genes involved in cellular redox, protein degradation, DNA repair, xenobiotic metabolism, and apoptosis, contributing to the prevention of colorectal cancer.
炎症性肠病（IBDs）与核因子红细胞2相关因子2（Nrf2）失调有关。已经发表了使用植物化合物作为IBD中Nrf2信号调节剂的体外和体内研究。然而，现有的综述都没有强调植物和植物化合物作为IBD模型和结肠炎相关结直肠癌中Nrf2调节剂的潜在整体情况。出于这些原因，本研究旨在构建一篇能够填补这一空白的综述。检索了PubMed、EMBASE、COCHRANE和谷歌学术数据库。文献综述表明，药用植物和植物化学物质通过增强Nrf2介导的II期解毒酶的表达并减少NF-κB相关炎症来调节IBD和IBD相关结直肠癌中的Nrf2。这些作用改善肠道环境、黏膜屏障、结肠和隐窝破坏，减少溃疡和微生物易位，从而降低疾病活动指数（DAI）。此外，Nrf2的调节可调控参与细胞氧化还原、蛋白质降解、DNA修复、外源性物质代谢和细胞凋亡的各种基因，有助于预防结直肠癌。
