Provincial-level Key Laboratory for Molecular Medicine of Major Diseases and The Prevention and Treatment with Traditional Chinese Medicine Research in Gansu Colleges and University, Gansu University of Chinese Medicine, Lanzhou 730000, China; College of Basic Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, China.
College of Public Health, Gansu University of Chinese Medicine, Lanzhou 730000, China; Key Laboratory for Transfer of Dunhuang Medicine at the Provincial and Ministerial Level, Gansu University of Chinese Medicine, Lanzhou 730000, China.
Biomed Pharmacother. 2023 Aug;164:114950. doi: 10.1016/j.biopha.2023.114950. Epub 2023 May 30.
Inflammatory bowel disease (IBD) is a special chronic intestinal inflammatory disease, which is mainly divided into Crohn's disease (CD) and ulcerative colitis (UC). Its occurrence is a complex process that regulated by multiple signaling pathways, including nuclear factor erythroid 2-related factor (Nrf2)/ antioxidant response element (ARE) signaling pathway. Nrf2/ARE pathway as the central defense mechanism against oxidative stress controls the expression of many antioxidant and anti-inflammatory genes in the nucleus, and plays a crucial role in the treatment of IBD. Various studies have proved that many natural compounds target Nrf2/ARE signaling pathway to treat IBD. Here, we introduced the regulatory mechanism of the Nrf2/ARE pathway, and its role in IBD and IBD complications (intestinal fibrosis and colorectal cancer (CRC)); summarized the research progress of Nrf2 targeted natural compounds and extracts in the treatment of IBD; and finally described the intestinal microbiota that alleviate or treat IBD via activating Nrf2/ARE signaling pathway. This review highlights the potential for targeting Nrf2/ARE pathway to treat IBD.
炎症性肠病（IBD）是一种特殊的慢性肠道炎症性疾病，主要分为克罗恩病（CD）和溃疡性结肠炎（UC）。其发生是一个受多种信号通路调节的复杂过程，包括核因子红细胞 2 相关因子（Nrf2）/抗氧化反应元件（ARE）信号通路。Nrf2/ARE 通路作为对抗氧化应激的中央防御机制，在核内控制许多抗氧化和抗炎基因的表达，在治疗 IBD 中起着至关重要的作用。各种研究已经证明，许多天然化合物通过靶向 Nrf2/ARE 信号通路来治疗 IBD。在这里，我们介绍了 Nrf2/ARE 通路的调节机制，及其在 IBD 及其并发症（肠道纤维化和结直肠癌（CRC））中的作用；总结了 Nrf2 靶向天然化合物和提取物在治疗 IBD 中的研究进展；最后描述了通过激活 Nrf2/ARE 信号通路来减轻或治疗 IBD 的肠道微生物群。本综述强调了靶向 Nrf2/ARE 通路治疗 IBD 的潜力。
