Fuke Nobuo, Yamashita Takahiro, Shimizu Sunao, Matsumoto Mai, Sawada Kaori, Jung Songee, Tokuda Itoyo, Misawa Mina, Suzuki Shigenori, Ushida Yusuke, Mikami Tatsuya, Itoh Ken, Suganuma Hiroyuki
Innovation Division, KAGOME Co., Ltd., 17 Nishitomiyama, Nasushiobara 329-2762, Tochigi, Japan.
Department of Vegetable Life Science, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, Aomori, Japan.
Metabolites. 2023 Feb 9;13(2):250. doi: 10.3390/metabo13020250.
The influx of intestinal bacteria-derived lipopolysaccharide (LPS) into the blood has attracted attention as a cause of diseases. The aim of this study is investigating the associations between the influx of LPS, dietary factors, gut microbiota, and health status in the general adult population. Food/nutrient intake, gut microbiota, health status and plasma LPS-binding protein (LBP; LPS exposure indicator) were measured in 896 residents (58.1% female, mean age 54.7 years) of the rural Iwaki district of Japan, and each correlation was analyzed. As the results, plasma LBP concentration correlated with physical (right/left arms' muscle mass [ = -0.02, -0.03]), renal (plasma renin activity [ = 0.27], urine albumin creatinine ratio [ = 0.50]), adrenal cortical (cortisol [ = 0.14]), and thyroid function (free thyroxine [ = 0.05]), iron metabolism (serum iron [ = -0.14]), and markers of lifestyle-related diseases (all s < 0.20). Plasma LBP concentration were mainly negatively correlated with vegetables/their nutrients intake (all ≤ -0.004, s < 0.20). Plasma LBP concentration was positively correlated with the proportion of ( = 0.32), ( = 0.56), and ( = 0.65); and negatively correlated with ( = -0.57) (all s < 0.20). Dietary factors correlated with plasma LBP concentration correlated with positively (all s ≥ 0.07) or negatively (all s ≤ -0.07) the proportion of these bacteria (all s < 0.20). Our results suggested that plasma LBP concentration in the Japanese general adult population was associated with various health issues, and that dietary habit was associated with plasma LBP concentration in relation to the intestinal bacteria.
肠道细菌衍生的脂多糖（LPS）流入血液作为疾病的一个病因已引起关注。本研究的目的是调查普通成年人群中LPS流入、饮食因素、肠道微生物群和健康状况之间的关联。对日本磐城农村地区的896名居民（女性占58.1%，平均年龄54.7岁）进行了食物/营养摄入、肠道微生物群、健康状况和血浆LPS结合蛋白（LBP；LPS暴露指标）的测量，并分析了各项之间的相关性。结果显示，血浆LBP浓度与身体状况（右臂/左臂肌肉量[=-0.02，-0.03]）、肾脏功能（血浆肾素活性[=0.27]、尿白蛋白肌酐比值[=0.50]）、肾上腺皮质功能（皮质醇[=0.14]）、甲状腺功能（游离甲状腺素[=0.05]）、铁代谢（血清铁[=-0.14]）以及生活方式相关疾病的标志物（所有s<0.20）相关。血浆LBP浓度主要与蔬菜/其营养成分的摄入量呈负相关（所有≤-0.004，s<0.20）。血浆LBP浓度与[=0.32]、[=0.56]和[=0.65]的比例呈正相关；与[=-0.57]呈负相关（所有s<0.20）。与血浆LBP浓度相关的饮食因素与这些细菌的比例呈正相关（所有s≥0.07）或负相关（所有s≤-0.07）（所有s<0.20）。我们的结果表明，日本普通成年人群的血浆LBP浓度与各种健康问题相关，并且饮食习惯与血浆LBP浓度在肠道细菌方面存在关联。
