Ugalde-Arbizu Maider, Aguilera-Correa John Jairo, García-Almodóvar Victoria, Ovejero-Paredes Karina, Díaz-García Diana, Esteban Jaime, Páez Paulina L, Prashar Sanjiv, San Sebastian Eider, Filice Marco, Gómez-Ruiz Santiago
Departamento de Química Aplicada, Facultad de Química, Euskal Herriko Unibertsitatea (UPV/EHU), Paseo Manuel Lardizabal 3, 20018 Donostia San Sebastián, Spain.
Clinical Microbiology Department, IIS-Fundación Jiménez Diaz, UAM, Avenida Reyes 15 Católicos 2, 28037 Madrid, Spain.
Pharmaceutics. 2023 Feb 7;15(2):560. doi: 10.3390/pharmaceutics15020560.
Five different silica nanoparticles functionalized with vitamin B12, a derivative of coumarin found in green plants and a minimum content of an organotin(IV) fragment (, , , and ), were identified as excellent anticancer agents against triple negative breast cancer, one of the most diagnosed and aggressive cancerous tumors, with very poor prognosis. Notably, compound shows selectivity for cancer cells and excellent luminescent properties detectable by imaging techniques once internalized. The same compound is also able to interact with and nearly eradicate biofilms of , the most common bacteria isolated from chronic wounds and burns, whose treatment is a clinical challenge. is efficiently internalized by bacteria in a biofilm state and destroys the latter through reactive oxygen species (ROS) generation. Its internalization by bacteria was also efficiently monitored by fluorescence imaging. Since silica nanoparticles are particularly suitable for oral or topical administration, and considering both its anticancer and antibacterial activity, represents a new dual-condition theranostic agent, based primarily on natural products or their derivatives and with only a minimum amount of a novel metallodrug.
五种不同的二氧化硅纳米颗粒被鉴定为对抗三阴性乳腺癌的优秀抗癌剂。这五种纳米颗粒分别用维生素B12、绿色植物中发现的香豆素衍生物以及最低含量的有机锡（IV）片段（、、、和）进行了功能化修饰。三阴性乳腺癌是最常被诊断出且侵袭性很强的癌性肿瘤之一，预后非常差。值得注意的是，化合物一旦被内化，通过成像技术可检测到其对癌细胞具有选择性以及出色的发光特性。同样的化合物还能够与从慢性伤口和烧伤中分离出的最常见细菌——的生物膜相互作用并几乎将其根除，对这种细菌的治疗是一项临床挑战。处于生物膜状态的细菌能有效地内化该化合物，并通过产生活性氧（ROS）来破坏生物膜。通过荧光成像也能有效地监测细菌对其的内化情况。由于二氧化硅纳米颗粒特别适合口服或局部给药，并且考虑到其抗癌和抗菌活性，该化合物代表了一种新型的双功能诊疗剂，主要基于天然产物或其衍生物，且仅含有少量新型金属药物。
