Chair of Medical Biotechnology, Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, Poland.
Nanotechnology. 2019 Aug 2;30(31):315101. doi: 10.1088/1361-6528/ab19d3. Epub 2019 Apr 16.
Magnetoliposomes are promising candidates for the development of selective drug delivery systems in the treatment of cancer. Those nanosystems were tested as carriers of a strong chemotherapeutic agent, doxorubicin, which is used against breast cancer. Herein, the magnetic properties of hydrophobic iron oxide nanoparticles located exclusively in the lipid bilayer were used to release this drug from the magnetoliposomes. The cytotoxic activity of the nanostructures against the normal and cancer cell lines was determined on the basis of cells viability measurement after incubation with different concentrations of these nanomaterials. In the same way, the effectiveness of killing cancer cells in combination with exposure to magnetic field was also evaluated. These experiments confirmed that the nanostructures composed of liposomes and magnetic nanoparticles are not cytotoxic. However, magnetoliposomes loaded with doxorubicin were effective and selective in reducing the viability of human breast tumor cell lines. In this paper, we demonstrated the promising application of the studied magnetoliposomes as carriers of doxorubicin released under the influence of magnetic field in tumor cells.
磁脂质体是开发用于癌症治疗的选择性药物传递系统的有前途的候选物。这些纳米系统被测试为强化疗药物阿霉素的载体，阿霉素用于治疗乳腺癌。在此，将专门位于脂质双层中的疏水性氧化铁纳米粒子的磁性能用于从磁脂质体中释放这种药物。通过用不同浓度的这些纳米材料孵育后测量细胞活力，来确定纳米结构对正常和癌细胞系的细胞毒性活性。同样，还评估了与磁场暴露相结合杀死癌细胞的效果。这些实验证实，由脂质体和磁性纳米粒子组成的纳米结构没有细胞毒性。然而，载有阿霉素的磁脂质体在降低人乳腺癌肿瘤细胞系的活力方面是有效且具有选择性的。在本文中，我们证明了所研究的磁脂质体作为在肿瘤细胞中磁场作用下释放的阿霉素载体的有前途的应用。
