Crosby Tyler, Adkins Lacey, McWhorter Andrew, Kunduk Melda, Dunham Michael
Louisiana State University Health Science Center, New Orleans - Department of Otolaryngology, Head and Neck Surgery, 533 Bolivar Street, Suite 566, New Orleans, LA 70112, USA; Department of Otolaryngology-Head and Neck Surgery, NYU Langone Health, New York, New York.
Louisiana State University Health Science Center, New Orleans - Department of Otolaryngology, Head and Neck Surgery, 533 Bolivar Street, Suite 566, New Orleans, LA 70112, USA; Our Lady of the Lake Regional Medical Center, Voice Center, 4950 Essen Ln Ste 401, Baton Rouge, LA 70809, USA.
Respir Physiol Neurobiol. 2023 Jun;312:104037. doi: 10.1016/j.resp.2023.104037. Epub 2023 Feb 25.
3D models of airway lumens were created from CT scans of 19 patients with laryngotracheal stenosis. Computational fluid dynamics (CFD) simulations were completed for each, and results were compared to measured peak inspiratory flow rate, grade of lumen constriction, and measures of airway geometry. Results demonstrate flow resistance and shear stress correlate with degree of lumen constriction and absolute cross-sectional area as well as flow rate. Flow recirculation depends on airway constriction but does not vary with flow rate. Resistance and wall shear stress did not correlate well with functional measures. Flow recirculation did differ between subjects with higher functional measures and subjects with lower functional measures. This analysis provides mathematical models to predict airway resistance, wall shear stress, and flow reversal according lumen constriction and inspiratory flow rate. It suggests aerodynamic factors such as flow recirculation play a role in differences in functional performance between patients with similar airway measures.
通过对19例喉气管狭窄患者的CT扫描创建气道管腔的3D模型。对每个模型完成计算流体动力学（CFD）模拟，并将结果与测量的吸气峰值流速、管腔狭窄程度和气道几何测量值进行比较。结果表明，流动阻力和剪切应力与管腔狭窄程度、绝对横截面积以及流速相关。流动再循环取决于气道狭窄，但不随流速变化。阻力和壁面剪切应力与功能测量值相关性不佳。功能测量值较高的受试者与功能测量值较低的受试者之间的流动再循环确实存在差异。该分析提供了数学模型，以根据管腔狭窄和吸气流速预测气道阻力、壁面剪切应力和流动逆转。这表明诸如流动再循环等空气动力学因素在气道测量相似的患者之间的功能表现差异中起作用。
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