非高密度脂蛋白胆固醇和臂踝脉搏波速度对心血管疾病风险的个体及联合作用：基于开滦队列的前瞻性研究结果

Individual and combined contributions of non-high-density lipoprotein cholesterol and brachial-ankle pulse wave velocity to cardiovascular disease risk: Results of a prospective study using the Kailuan cohort.

作者信息

Zheng Qiongbing, Wang Hui, Wang Xianxuan, Lan Youmian, Wu Weiqiang, Yu Xinran, Huang Zegui, Chen Zekai, Cai Zefeng, Lin Qi, Zhou Houshi, Zhu Yongdong, Liu Muyuan, Wu Kuangyi, Zheng Huancong, Wu Shouling, Chen Youren

机构信息

Department of Neurology, Shantou Central Hospital, Shantou, China.

School of Nursing, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China.

出版信息

Front Cardiovasc Med. 2023 Feb 9;10:1105464. doi: 10.3389/fcvm.2023.1105464. eCollection 2023.

DOI:10.3389/fcvm.2023.1105464

PMID:36844718

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9947564/

Abstract

OBJECTIVE

We aimed to characterize the relationship of a combination of circulating non-high-density lipoprotein-cholesterol (non-HDL-C) concentration and brachial-ankle pulse wave velocity (baPWV) with cardiovascular disease (CVD).

METHODS

We performed a prospective cohort study of the residents of the Kailuan community, with data from a total of 45,051 participants being included in the final analysis. The participants were allocated to four groups according to their non-HDL-C and baPWV status, each of which was categorized as high or normal. Cox proportional hazards models were used to explore the relationships of non-HDL-C and baPWV, individually and in combination, with the incidence of CVD.

RESULTS

During the 5.04-year follow-up period, 830 participants developed CVD. Compared with the Normal non-HDL-C group independently, the multivariable adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for CVD in the High non-HDL-C was 1.25 (1.08-1.46). Compared with the Normal baPWV group independently, the HRs and 95% CIs for CVD in the High baPWV was 1.51 (1.29-1.76). In addition, compared with the Normal both non-HDL-C and baPWV group, the HRs and 95% CIs for CVD in the High non-HDL-C and normal baPWV, Normal non-HDL-C and high baPWV, and High both non-HDL-C and baPWV groups were 1.40 (1.07-1.82), 1.56 (1.30-1.88), and 1.89 (1.53-2.35), respectively.

CONCLUSION

High non-HDL-C concentration and high baPWV are independently associated with a higher risk of CVD, and individuals with high both non-HDL-C and baPWV are at a still higher risk of CVD.

摘要

目的

我们旨在描述循环中非高密度脂蛋白胆固醇（non-HDL-C）浓度与臂踝脉搏波速度（baPWV）的组合与心血管疾病（CVD）之间的关系。

方法

我们对开滦社区居民进行了一项前瞻性队列研究，最终分析纳入了总共45051名参与者的数据。参与者根据其non-HDL-C和baPWV状态被分为四组，每组又分为高或正常。采用Cox比例风险模型分别及联合探讨non-HDL-C和baPWV与CVD发病率的关系。

结果

在5.04年的随访期内，830名参与者发生了CVD。与non-HDL-C正常组相比，non-HDL-C高组发生CVD的多变量调整风险比（HR）和95%置信区间（CI）为1.25（1.08 - 1.46）。与baPWV正常组相比，baPWV高组发生CVD的HR和95%CI为1.51（1.29 - 1.76）。此外，与non-HDL-C和baPWV均正常组相比，non-HDL-C高且baPWV正常组、non-HDL-C正常且baPWV高组以及non-HDL-C和baPWV均高组发生CVD的HR和95%CI分别为1.40（1.07 - 1.82）、1.56（1.30 - 1.88）和1.89（1.53 - 2.35）。