血脂谱与动脉僵硬度之间的关联：基于横断面研究的二次分析。
Association between lipid profiles and arterial stiffness: A secondary analysis based on a cross-sectional study.
作者信息
Wang Long, Zhi Fu, Gao Beibei, Ni Jie, Liu Yihai, Mo Xuming, Huang Jinyu
机构信息
Department of Cardiology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Center for Translational Medicine, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
出版信息
J Int Med Res. 2020 Jul;48(7):300060520938188. doi: 10.1177/0300060520938188.
OBJECTIVES
The relationship between lipid levels and arterial stiffness remains controversial. Therefore, we aimed to determine the relationship between lipid profiles and brachial-ankle pulse wave velocity (baPWV) as an indicator of arterial stiffness.
METHODS
A total of 909 participants aged 24 to 84 years were stratified into four baPWV quartiles in our study. Serum lipids, baPWV, and other variables of the participants were measured. Univariable and multivariable linear regression analyses were used to examine the relationships between lipid parameters and baPWV.
RESULTS
The highest baPWV quartile group had higher aspartate transaminase, alanine aminotransferase, plasma glucose, total cholesterol, triglyceride (TG), and low-density lipoprotein cholesterol levels and maximum ankle-brachial index, and lower high-density lipoprotein cholesterol levels and estimated glomerular filtration rate. Univariate regression analysis showed that total cholesterol, TG, and low-density lipoprotein cholesterol levels were positively related and high-density lipoprotein cholesterol levels were negatively related to baPWV. After adjusting for age, body mass index, smoking status, aspartate transaminase, alanine aminotransferase, plasma glucose, and estimated glomerular filtration rate, only TG levels were correlated with baPWV (β = 0.075).
CONCLUSIONS
Four lipid variates are associated with arterial stiffness, and TG levels are positively related to arterial stiffness, independent of cardiovascular risks and liver function.
目的
血脂水平与动脉僵硬度之间的关系仍存在争议。因此，我们旨在确定血脂谱与作为动脉僵硬度指标的臂踝脉搏波速度（baPWV）之间的关系。
方法
在我们的研究中，共有909名年龄在24至84岁之间的参与者被分为四个baPWV四分位数组。测量了参与者的血脂、baPWV及其他变量。采用单变量和多变量线性回归分析来检验血脂参数与baPWV之间的关系。
结果
baPWV最高的四分位数组具有更高的天冬氨酸转氨酶、丙氨酸转氨酶、血糖、总胆固醇、甘油三酯（TG）和低密度脂蛋白胆固醇水平以及最大踝臂指数，而高密度脂蛋白胆固醇水平和估算肾小球滤过率较低。单变量回归分析表明，总胆固醇、TG和低密度脂蛋白胆固醇水平与baPWV呈正相关，高密度脂蛋白胆固醇水平与baPWV呈负相关。在调整年龄、体重指数、吸烟状况、天冬氨酸转氨酶、丙氨酸转氨酶、血糖和估算肾小球滤过率后，只有TG水平与baPWV相关（β = 0.075）。
结论
四种血脂变量与动脉僵硬度相关，且TG水平与动脉僵硬度呈正相关，独立于心血管风险和肝功能。
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