喀麦隆执业医生使用第三代头孢菌素的态度和做法。

Attitudes and Practices of the Use of Third-Generation Cephalosporins among Medical Doctors Practicing in Cameroon.

机构信息

Department of Biomedical Sciences, Faculty of Health Sciences, University of Buea, Buea, Cameroon.

Antimicrobial and Biocontrol Agents Unit, Laboratory for Phytobiochemistry and Medicinal Plants Studies, University of Yaounde 1, Yaoundé, Cameroon.

出版信息

Int J Clin Pract. 2023 Feb 15;2023:8074413. doi: 10.1155/2023/8074413. eCollection 2023.

DOI:10.1155/2023/8074413

PMID:36846498

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9946740/

Abstract

BACKGROUND

Third-generation cephalosporins (3GC) are among the most prescribed antibiotics worldwide. Antibiotic resistance, usually due to misuse and overuse, is a feared complication of public health concern. However, there are limited data in Cameroon concerning the knowledge and use of 3GC in our health services. The aim of this study was to assess the knowledge and use of 3GC among medical doctors in Cameroon and to generate baseline information for a wider scale research and policy implementation.

METHODS

This study was a cross-sectional study conducted among medical doctors practicing in Cameroon in general. Convenience sampling was used and the data were collected from both the online questionnaire and the review of files of patients admitted and discharged within the month of April 2021 and analysed with the use of IBM SPSS v25. . A total of 52 respondents from the online questionnaire and 31 reviewed files were retained. Of the respondents, 27% were female and 73% were male. The mean age and years of experience were 29.6 ± 2.9 and 3.6 ± 2.1 years, respectively. Only 32.7% had correct knowledge of the number of generations of cephalosporins, and 48.1% had knowledge of the antimicrobial target. All medical doctors (MD) identified ceftriaxone as a 3GC, and it was the most commonly prescribed 3GC (71%). Most of the MD considered 3GC to be an efficient antibiotic. Just over half (54.7%) knew the correct posology of ceftriaxone. Only 17% and 9.4% knew the right posology for cefotaxime and ceftazidime, respectively, for the management of early-onset neonatal infection (EONNI). The misuse of 3GC was mostly attributed to nurses, MD, and poor institutional policies.

CONCLUSION

There is average knowledge on 3GC among MD, with ceftriaxone being the most widely known and prescribed. Misuse is common among nurses and doctors. Poor institutional policies and limited laboratory capacities are to be blamed.

摘要

背景

第三代头孢菌素（3GC）是全球应用最广泛的抗生素之一。抗生素耐药性通常是由于滥用和过度使用引起的，是公共卫生关注的一个令人担忧的并发症。然而，喀麦隆关于我们的卫生服务中 3GC 的知识和使用的数据有限。本研究旨在评估喀麦隆医生对 3GC 的了解和使用情况，并为更广泛的研究和政策实施提供基线信息。

方法

这是一项横断面研究，在喀麦隆的医生中进行。采用便利抽样，于 2021 年 4 月收集了在线问卷和患者入院及出院记录的审查数据，并使用 IBM SPSS v25 进行分析。从在线问卷中保留了 52 名受访者和 31 份审查文件。受访者中，女性占 27%，男性占 73%。平均年龄和工作年限分别为 29.6±2.9 岁和 3.6±2.1 年。只有 32.7%的人正确了解头孢菌素的代际数，48.1%的人了解抗菌药物的靶标。所有医生都将头孢曲松识别为 3GC，它是最常开的 3GC（71%）。大多数医生认为 3GC 是一种有效的抗生素。超过一半（54.7%）知道头孢曲松的正确剂量。只有 17%和 9.4%的人知道头孢噻肟和头孢他啶治疗早发性新生儿感染（EONNI）的正确剂量。3GC 的滥用主要归咎于护士、医生和不良的机构政策。