Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, CV4 7AL, UK.
Microbiology (Reading). 2023 Feb;169(2). doi: 10.1099/mic.0.001306.
is the primary cause for nosocomial infective diarrhoea. For a successful infection, must navigate between resident gut bacteria and the harsh host environment. The perturbation of the intestinal microbiota by broad-spectrum antibiotics alters the composition and the geography of the gut microbiota, deterring colonization resistance, and enabling to colonize. This review will discuss how interacts with and exploits the microbiota and the host epithelium to infect and persist. We provide an overview of virulence factors and their interactions with the gut to aid adhesion, cause epithelial damage and mediate persistence. Finally, we document the host responses to , describing the immune cells and host pathways that are associated and triggered during infection.
是医院感染性腹泻的主要原因。为了成功感染，必须在常驻肠道细菌和恶劣的宿主环境之间进行导航。广谱抗生素对肠道微生物群的干扰改变了微生物群的组成和地理分布，阻止了定植抗性，并使能够定植。这篇综述将讨论 如何与微生物群和宿主上皮相互作用，从而感染和持续存在。我们提供了 毒力因子及其与肠道相互作用的概述，以帮助粘附、引起上皮损伤和介导持续存在。最后，我们记录了宿主对 的反应，描述了与 感染相关和触发的免疫细胞和宿主途径。
