Zezulka A V, Gill J S, Beevers D G
University Department of Medicine, Dudley Road Hospital, Birmingham, UK.
Postgrad Med J. 1987 Apr;63(738):257-61. doi: 10.1136/pgmj.63.738.257.
A prospective case control study routine haematological parameters was conducted in 294 healthy Black and White age/sex-matched subjects. The most important finding relevant to clinical practice was a reduction of total white cell count in Blacks due mainly to reduced neutrophil numbers. Twenty-one percent of sickle negative Blacks had white cell counts below the lowest value seen in Whites. The haemoglobin concentration, erythrocyte mean cell volume and monocyte count were also significantly lower amongst Blacks though lymphocyte counts were higher. The racial differences in haemoglobin and white count were not accounted for by differences in smoking and drinking habits. They were also found when Blacks with sickle cell trait were compared to age/sex-matched Whites and in others taking the oral contraceptive pill. Awareness of racial group should aid interpretation of routine tests and avoid unnecessary investigation of normal 'neutropenic' Blacks.
在294名年龄和性别匹配的健康黑人和白人受试者中进行了一项关于常规血液学参数的前瞻性病例对照研究。与临床实践相关的最重要发现是黑人的总白细胞计数减少，主要原因是中性粒细胞数量减少。21%的镰状细胞阴性黑人的白细胞计数低于白人中所见的最低值。黑人的血红蛋白浓度、红细胞平均细胞体积和单核细胞计数也显著较低，尽管淋巴细胞计数较高。吸烟和饮酒习惯的差异并不能解释血红蛋白和白细胞计数的种族差异。当将具有镰状细胞特征的黑人与年龄和性别匹配的白人以及其他服用口服避孕药的人进行比较时，也发现了这些差异。了解种族群体应有助于对常规检查结果的解读，并避免对正常的“中性粒细胞减少”黑人进行不必要的检查。
