Diana Rosita, Gentile Francesco Silvio, Concilio Simona, Petrella Antonello, Belvedere Raffaella, Schibeci Martina, Arciello Angela, Di Costanzo Luigi, Panunzi Barbara
Department of Agricultural Sciences, University of Naples Federico II, 80055 Napoli, Italy.
Department of Pharmacy, University of Salerno, 84084 Salerno, Italy.
Polymers (Basel). 2023 Feb 10;15(4):883. doi: 10.3390/polym15040883.
Among modern biomaterials, hybrid tools containing an organic component and a metal cation are recognized as added value, and, for many advanced biomedical applications, synthetic polymers are used as thin protective/functional coatings for medical or prosthetic devices and implants. These materials require specific non-degradability, biocompatibility, antimicrobial, and antiproliferative properties to address safety aspects concerning their use in medicine. Moreover, bioimaging monitoring of the biomedical device and/or implant through biological tissues is a desirable ability. This article reports a novel hybrid metallopolymer obtained by grafting zinc-coordinated fragments to an organic polymeric matrix. This hybrid polymer, owing to its relevant emission in the deep red to near-infrared (DR/NIR) region, is monitorable; therefore, it represents a potential material for biomedical coating. Furthermore, it shows good biocompatibility and adhesion properties and excellent stability in slightly acidic/basic water solutions. Finally, in contact with the superficial layers of human skin, it shows antimicrobial properties against bacterial strains.
在现代生物材料中，含有有机成分和金属阳离子的混合工具被认为具有附加价值，并且在许多先进的生物医学应用中，合成聚合物被用作医疗或假体装置及植入物的薄保护/功能涂层。这些材料需要具备特定的不可降解性、生物相容性、抗菌性和抗增殖特性，以解决其在医学应用中的安全问题。此外，通过生物组织对生物医学装置和/或植入物进行生物成像监测是一种理想的能力。本文报道了一种通过将锌配位片段接枝到有机聚合物基质上获得的新型混合金属聚合物。这种混合聚合物由于在深红色至近红外（DR/NIR）区域有相关发射，是可监测的；因此，它是一种潜在的生物医学涂层材料。此外，它具有良好的生物相容性和粘附性能，在微酸性/碱性水溶液中具有出色的稳定性。最后，与人体皮肤表层接触时，它对细菌菌株具有抗菌性能。
