Sevim Çiğdem, Akpınar Erol, Aksu Emrah Hicazi, Ömür Ali Doğan, Yıldırım Serkan, Kara Mehtap, Bolat İsmail, Tsatsakis Aristides, Mesnage Robin, Golokhvast Kirill S, Uzunçakmak Sevgi Karabulut, Ersoylu Rabia Nilüfer
Department of Medical Pharmacology, Medicine Faculty, Kastamonu University, 37150 Kastamonu, Turkey.
Department of Medical Pharmacology, Medicine Faculty, Ataturk University, 25240 Erzurum, Turkey.
Toxics. 2023 Feb 12;11(2):170. doi: 10.3390/toxics11020170.
The potential health-promoting effects of probiotics against intoxication by pesticides is a topic of increasing commercial interest with limited scientific evidence. In this study, we aimed to investigate the positive effects of probiotic on the male reproductive system under low dose neonicotinoid pesticide exposure conditions. We observed that acetamiprid and imidacloprid caused a degeneration and necrosis of the spermatocytes in the tubular wall, a severe edema of the intertubular region and a hyperemia. This was concomittant to increased levels of 8-hydroxy-2'-deoxyguanosine reflecting oxidative stress, and an increase in caspase 3 expression, reflecting apoptosis. According to our results, supplementation mitigates these toxic effects. Further in vivo and clinical studies are needed to clarify the molecular mechanisms of protection. Altogether, our study reinforces the burden of evidence from emerging studies linking the composition of the gut microbiome to the function of the reproductive system.
益生菌对农药中毒的潜在健康促进作用是一个商业利益日益增加但科学证据有限的话题。在本研究中，我们旨在调查在低剂量新烟碱类农药暴露条件下益生菌对雄性生殖系统的积极影响。我们观察到，啶虫脒和吡虫啉导致管壁精母细胞变性和坏死、管间区域严重水肿和充血。这伴随着反映氧化应激的8-羟基-2'-脱氧鸟苷水平升高，以及反映细胞凋亡的半胱天冬酶3表达增加。根据我们的结果，补充益生菌可减轻这些毒性作用。需要进一步的体内和临床研究来阐明保护的分子机制。总之，我们的研究强化了新兴研究中关于肠道微生物群组成与生殖系统功能之间联系的证据负担。
