沙特麦加的戊型肝炎病毒（HEV）：一项基于人群的血清流行率研究。

Hepatitis E Virus (HEV) in Makkah, Saudi Arabia: A Population-Based Seroprevalence Study.

机构信息

Special Infectious Agents Unit-BSL3, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21362, Saudi Arabia.

Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia.

出版信息

Viruses. 2023 Feb 9;15(2):484. doi: 10.3390/v15020484.

DOI:10.3390/v15020484

PMID:36851698

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9964995/

Abstract

BACKGROUND

The Hepatitis E virus (HEV) is a common cause of viral hepatitis worldwide. Little is known about the seroprevalence of HEV in the general population of Saudi Arabia.

METHODS

A community-based cross-sectional HEV seroprevalence study was conducted in Makkah, Saudi Arabia. Anti-HEV IgG antibodies were detected in sera using an in-house ELISA. The frequency of HEV sageerology and its correlation with demographic, and environmental factors were evaluated.

RESULTS

Enrollment consisted of 1329 individuals, ages ranged from 8 to 88 years, the mean age was 30.17 years, the median age was 28yrs, and the male: female ratio was 1.15. The overall seroprevalence was 23.8% (316/1329). Males had significantly higher seroprevalence than females (66.1 vs. 33.9%; < 0.001). Seroprevalence had significant correlations with age, occupation, and lack of regular water supply and housing conditions.

CONCLUSIONS

This is the first HEV community-based seroprevalence study from Saudi Arabia. Results show that the HEV is endemic in Makkah and affects all age groups and occupations. HEV affects more males than females and those living in crowded accommodations without a regular supply of water. Further studies are required across all regions of Saudi Arabia to determine the country's seroprevalence of active or past infection using tests for HEV IgG, HEV IgM antibodies and/or HEV RNA and underlying determinants of transmission.

摘要

背景

戊型肝炎病毒（HEV）是全球范围内病毒性肝炎的常见病因。沙特阿拉伯普通人群中 HEV 的血清流行率知之甚少。

方法

在沙特阿拉伯麦加进行了一项基于社区的横断面 HEV 血清流行率研究。使用内部 ELISA 检测血清中的抗-HEV IgG 抗体。评估了 HEV 血清学的频率及其与人口统计学和环境因素的相关性。

结果

纳入了 1329 名年龄在 8 至 88 岁之间的个体，平均年龄为 30.17 岁，中位数年龄为 28 岁，男女比例为 1.15。总体血清流行率为 23.8%（316/1329）。男性的血清流行率明显高于女性（66.1%比 33.9%；<0.001）。血清流行率与年龄、职业以及缺乏定期供水和住房条件显著相关。

结论

这是沙特阿拉伯首例基于社区的 HEV 血清流行率研究。结果表明，HEV 在麦加流行，影响所有年龄组和职业。HEV 感染男性多于女性，且那些居住在拥挤住所、没有定期供水的人感染的风险更高。需要在沙特阿拉伯所有地区进行进一步研究，以确定该国使用 HEV IgG、HEV IgM 抗体和/或 HEV RNA 检测以及传播的潜在决定因素进行的现症或既往感染的血清流行率。