Department of Plants, Soils, and Climate/Center for Integrated BioSystems, College of Agriculture and Applied Sciences, Utah State University, Logan, UT 84322, USA.
Bioinformatics Facility, Center for Integrated BioSystems, College of Agriculture and Applied Sciences, Utah State University, Logan, UT 84322, USA.
Viruses. 2023 Feb 10;15(2):492. doi: 10.3390/v15020492.
SARS-CoV-2, a novel betacoronavirus strain, has caused a pandemic that has claimed the lives of nearly 6.7M people worldwide. Vaccines and medicines are being developed around the world to reduce the disease spread, fatality rates, and control the new variants. Understanding the protein-protein interaction mechanism of SARS-CoV-2 in humans, and their comparison with the previous SARS-CoV and MERS strains, is crucial for these efforts. These interactions might be used to assess vaccination effectiveness, diagnose exposure, and produce effective biotherapeutics. Here, we present the HuCoPIA database, which contains approximately 100,000 protein-protein interactions between humans and three strains (SARS-CoV-2, SARS-CoV, and MERS) of betacoronavirus. The interactions in the database are divided into common interactions between all three strains and those unique to each strain. It also contains relevant functional annotation information of human proteins. The HuCoPIA database contains SARS-CoV-2 (41,173), SARS-CoV (31,997), and MERS (26,862) interactions, with functional annotation of human proteins like subcellular localization, tissue-expression, KEGG pathways, and Gene ontology information. We believe HuCoPIA will serve as an invaluable resource to diverse experimental biologists, and will help to advance the research in better understanding the mechanism of betacoronaviruses.
SARS-CoV-2，一种新型的β冠状病毒株，已经引发了一场全球大流行，导致近 670 万人死亡。全球正在开发疫苗和药物，以减少疾病传播、死亡率，并控制新的变异株。了解人类中 SARS-CoV-2 的蛋白质-蛋白质相互作用机制，以及它们与之前的 SARS-CoV 和 MERS 株的比较，对于这些努力至关重要。这些相互作用可能用于评估疫苗的有效性、诊断暴露情况和产生有效的生物治疗药物。在这里，我们展示了 HuCoPIA 数据库，其中包含了大约 10 万个人类与三种β冠状病毒株（SARS-CoV-2、SARS-CoV 和 MERS）之间的蛋白质-蛋白质相互作用。数据库中的相互作用分为三种株系共有相互作用和每种株系特有的相互作用。它还包含了人类蛋白质的相关功能注释信息。HuCoPIA 数据库包含了 SARS-CoV-2（41173）、SARS-CoV（31997）和 MERS（26862）的相互作用，以及人类蛋白质的功能注释，如亚细胞定位、组织表达、KEGG 通路和基因本体论信息。我们相信 HuCoPIA 将成为各种实验生物学家的宝贵资源，并有助于推进对β冠状病毒机制的更好理解的研究。
