Gachályi A, Naményi J, Szegedi I, Varga L P
Frédéric Joliot-Curie, National Research Institute for Radiobiology and Radiohygiene, Budapest, Hungary.
Radiat Res. 1987 Nov;112(2):312-7.
The individual effects of desferrioxamine B (DFOA), Na3Ca diethylenetriaminepentaacetic acid (DTPA), Na-salicylate, DL-penicillamine, and 2-aminoethylisothiouronium bromide hydrobromide, as well as the effect of mixed-ligand treatment on the retention and elimination of 95Nb in mice have been examined. It was found that 95Nb could easily be mobilized by a single dose of DFOA, but the best result was obtained with the DFOA and DTPA combination. Mixed-ligand treatment did not change the deposition characteristics and translocation kinetics of 95Nb.
已研究了去铁胺B（DFOA）、二乙烯三胺五乙酸三钠钙（DTPA）、水杨酸钠、DL-青霉胺和氢溴酸2-氨基乙基异硫脲氢溴酸盐的个体效应，以及混合配体处理对95Nb在小鼠体内潴留和消除的影响。发现单剂量DFOA能轻易促使95Nb迁移，但DFOA和DTPA联合使用效果最佳。混合配体处理并未改变95Nb的沉积特征和转运动力学。
