Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Clin Transl Oncol. 2023 Feb;25(2):345-351. doi: 10.1007/s12094-022-02952-2. Epub 2022 Sep 27.
Leukemia is defined as a heterogeneous group of hematological cancers whose prevalence is on the rise worldwide. Despite the large body of studies, the etiology of leukemia has not been fully elucidated. Leukemia stem cells (LSCs) are a subpopulation of cancer cells that sustain the growth of the leukemic clone and are the main culprit for the maintenance of the neoplasm. In contrast to most leukemia cells, LSCs are resistant to chemo- and radiotherapy. Several recent studies demonstrated the altered expression profile of long non-coding RNAs (lncRNAs) in LSCs and shed light on the role of lncRNAs in the survival, proliferation, and differentiation of LSCs. LncRNAs are transcripts longer than 200 nucleotides that are implicated in several cellular and molecular processes such as gene expression, apoptosis, and carcinogenesis. Likewise, lncRNAs have shown a prognostic marker in leukemia patients and represent novel treatment options. Herein, we review the current knowledge concerning lncRNAs' implication in the pathogenesis of LSCs and discuss their prognostic, diagnostic, and therapeutic potential.
白血病被定义为一组异质性的血液系统癌症，其发病率在全球呈上升趋势。尽管有大量的研究，但白血病的病因尚未完全阐明。白血病干细胞（LSCs）是癌细胞的一个亚群，维持白血病克隆的生长，是肿瘤维持的主要罪魁祸首。与大多数白血病细胞不同，LSCs 对化疗和放疗有抗性。最近的几项研究表明，LSCs 中长链非编码 RNA（lncRNAs）的表达谱发生了改变，并揭示了 lncRNAs 在 LSCs 的存活、增殖和分化中的作用。lncRNAs 是长度超过 200 个核苷酸的转录本，参与了几个细胞和分子过程，如基因表达、细胞凋亡和癌变。同样，lncRNAs 已被证明是白血病患者的预后标志物，并代表了新的治疗选择。在此，我们综述了 lncRNAs 参与 LSCs 发病机制的最新知识，并讨论了它们在预后、诊断和治疗方面的潜在作用。
