Silver Paul J, Coles Michael J, Heath Candrice R, Parkman Henry P
Section of Gastroenterology, Department of Medicine, Temple University School of Medicine, Philadelphia, PA, USA.
Department of Dermatology, Temple University School of Medicine, Philadelphia, PA, USA.
Dig Dis Sci. 2023 Apr;68(4):1397-1402. doi: 10.1007/s10620-022-07803-2. Epub 2023 Feb 28.
Some patients with gastroparesis (Gp) report hair loss. The aim of this study was to investigate the prevalence of patient-reported hair loss in Gp patients, analyze hair loss association to severity of Gp and nutritional deficiencies, and study effects of multivitamin treatment on hair loss.
Patients with Gp were questioned about hair characteristics, Gp symptoms, and diet. Patients with hair loss had blood drawn for vitamin levels. Patients with hair loss were treated with daily multivitamin and assessed 8 weeks later.
Hair loss was reported in 65 of 143 patients with Gp (45.5%), occurring similarly in idiopathic and diabetic Gp. Hair loss was most commonly noticed while washing and/or combing hair. Patients with hair loss had more severe nausea, abdominal pain, stomach fullness, loss of appetite, abdominal discomfort, bloating, retching, stomach distension, vomiting, early satiety, postprandial fullness, and constipation. Hair loss patients lost more weight over prior 6 months. Patients with hair loss had similar gastric retention on gastric emptying scintigraphy. Overall, 29 of 61 (47.5%) patients with hair loss had at least one abnormal bloodwork result. After 8 weeks of treatment with a daily multivitamin, 17 of 41 (41%) patients had improvement in hair loss.
Hair loss occurred in 46% of patients with Gp, being associated with more severe symptoms, loss of weight, and several vitamin deficiencies, although not a specific one. Treatment with multivitamins improved hair loss in 40% of patients. Presence of hair loss in patients with Gp should prompt nutritional evaluation and supplementation.
一些胃轻瘫（Gp）患者报告有脱发症状。本研究的目的是调查Gp患者中患者报告的脱发患病率，分析脱发与Gp严重程度和营养缺乏的关联，并研究多种维生素治疗对脱发的影响。
对Gp患者询问头发特征、Gp症状和饮食情况。有脱发症状的患者进行血液维生素水平检测。有脱发症状的患者每日服用多种维生素进行治疗，并在8周后进行评估。
143例Gp患者中有65例（45.5%）报告有脱发，特发性和糖尿病性Gp患者的脱发情况相似。脱发最常在洗头和/或梳头时被注意到。有脱发症状的患者有更严重的恶心、腹痛、胃部饱胀感、食欲不振、腹部不适、腹胀、干呕、胃扩张、呕吐、早饱、餐后饱胀和便秘。脱发患者在过去6个月中体重减轻更多。脱发患者在胃排空闪烁扫描中的胃潴留情况相似。总体而言，61例脱发患者中有29例（47.5%）至少有一项血液检查结果异常。每日服用多种维生素治疗8周后，41例患者中有17例（41%）脱发情况有所改善。
46%的Gp患者出现脱发，与更严重的症状、体重减轻和多种维生素缺乏有关，尽管并非特定的某一种缺乏。多种维生素治疗使40%的患者脱发情况得到改善。Gp患者出现脱发应促使进行营养评估和补充。
