Section of Gastroenterology, Department of Medicine, Temple University School of Medicine, Philadelphia, PA, USA.
Dig Dis Sci. 2022 Aug;67(8):3872-3880. doi: 10.1007/s10620-021-07190-0. Epub 2021 Jul 29.
Patients with gastroparesis often consume only small meals due to early satiety.
(1) Describe meal eating characteristics of patients with gastroparesis; (2) Relate meal eating characteristics to symptoms, gastric emptying (GE), and body weight.
Patients with gastroparesis filled out questionnaires including Patient Assessment of Upper GI Symptoms (PAGI-SYM), and questionnaire about meal habits and body weight. Patients underwent gastric emptying scintigraphy.
Of 192 gastroparesis patients, 93% endorsed early satiety (ES) with severity of 3.7 ± 1.5 (scored from 0-5) and 93% endorsed postprandial fullness (PPF) with severity of 3.9 ± 1.3. Time spent consuming meals averaged 13.6 ± 17.7 min. Main reasons patients stopped eating were fullness (61%), nausea (48%), and abdominal pain (31%). Time spent eating correlated inversely with severity of nausea (r = -0.18, p < 0.05), stomach fullness (r = -0.21, p < 0.01), PPF (r = -0.23, p < 0.01), loss of appetite (r = -0.34, p < 0.01). Postprandial fullness lasted for 316 ± 344 min. Duration of PPF correlated with nausea (r = 0.30, p < 0.01), retching (r = 0.29, p < 0.01), vomiting (r = 0.28, p < 0.01), stomach fullness (r = 0.33, p < 0.01), loss of appetite (r = 0.35, p < 0.01), and constipation (r = 0.27, p < 0.01). Underweight patients had increased inability to finish a normal size meal (p < 0.01), loss of appetite (p < 0.01), and lower abdominal pain/discomfort (p < 0.05). Patients had lost 3.06 ± 10.60 kgs from their baseline weight. Weight loss correlated with nausea (r = 0.26, p < 0.01), ES (r = 0.30, p < 0.01), loss of appetite (r = 0.28, p < 0.01).
Early satiety and postprandial fullness were common with high severity. The main reasons for meal cessation were early satiety, nausea, and abdominal pain. Body weight and change in body weight were associated with symptoms of gastroparesis.
胃轻瘫患者常因早饱而只吃少量食物。
（1）描述胃轻瘫患者的进食特点；（2）将进食特点与症状、胃排空和体重联系起来。
胃轻瘫患者填写了包括患者上消化道症状评估（PAGI-SYM）问卷和饮食习惯及体重问卷。患者接受了胃排空闪烁扫描。
在 192 例胃轻瘫患者中，93%的患者报告早饱（ES），严重程度为 3.7±1.5（评分 0-5），93%的患者报告餐后饱胀（PPF），严重程度为 3.9±1.3。用餐时间平均为 13.6±17.7 分钟。患者停止进食的主要原因是饱胀（61%）、恶心（48%）和腹痛（31%）。进食时间与恶心（r=-0.18，p<0.05）、胃部饱胀（r=-0.21，p<0.01）、PPF（r=-0.23，p<0.01）和食欲减退（r=-0.34，p<0.01）的严重程度呈负相关。餐后饱胀持续 316±344 分钟。PPF 持续时间与恶心（r=0.30，p<0.01）、干呕（r=0.29，p<0.01）、呕吐（r=0.28，p<0.01）、胃部饱胀（r=0.33，p<0.01）、食欲减退（r=0.35，p<0.01）和便秘（r=0.27，p<0.01）相关。体重过轻的患者无法完成正常大小的餐食（p<0.01）、食欲减退（p<0.01）和下腹痛/不适（p<0.05）的情况更常见。患者体重较基线时减轻了 3.06±10.60 公斤。体重减轻与恶心（r=0.26，p<0.01）、ES（r=0.30，p<0.01）和食欲减退（r=0.28，p<0.01）相关。
早饱和餐后饱胀很常见，且严重程度较高。停止进食的主要原因是早饱、恶心和腹痛。体重和体重变化与胃轻瘫的症状有关。
