Brown H S, West C R, Bishop D R
Environment Technology, and Society Program, Clark University, Worcester, Massachusetts 01610.
Risk Anal. 1987 Sep;7(3):389-402. doi: 10.1111/j.1539-6924.1987.tb00474.x.
Chemical Health Effects Assessment Methodology (CHEM) is a new procedure for assessing hazardous properties of airborne toxic contaminants. CHEM evaluates substances for four major health effect categories: carcinogenicity, mutagenicity, reproductive/developmental toxicity, and toxic effects other than the first three. Three elements are considered in the assessment: weight of evidence, potency, and severity of effect. This approach produces a profile of toxic properties of chemicals which preserves their unique multidimensional character and highlights data gaps.
化学健康影响评估方法(CHEM)是一种评估空气中有毒污染物有害特性的新程序。CHEM对物质的四大健康影响类别进行评估:致癌性、致突变性、生殖/发育毒性以及除前三项之外的其他毒性作用。评估中考虑三个要素:证据权重、效力和影响的严重程度。这种方法生成了化学品毒性特性的概况,保留了其独特的多维度特征并突出了数据缺口。