Léonard A, Gerber G B
Teratogenicity and Mutagenicity Unit, Catholic University of Louvain, Brussels, Belgium.
Mutat Res. 1997 Aug;387(1):47-53. doi: 10.1016/s1383-5742(97)00022-7.
The paper reviews the information available concerning the mutagenic, carcinogenic and teratogenic effects of thallium. Data on mutagenic and carcinogenic risks of thallium and its compounds are extremely scanty but what is available does not indicate that thallium could be mutagenic or carcinogenic. At any rate, such risks, if they exist, would be submerged by the general high toxicity of thallium. On the other hand, thallium has some teratogenic properties, especially on cartilage and bone formation, although this seems to be more prominent in chicks than in mammals. Nevertheless, pregnant women should not be exposed to doses of thallium which might produce toxic symptoms; exposure to lower doses such as might occur near thallium-emitting plants is probably not embryotoxic.
本文综述了有关铊的诱变、致癌和致畸作用的现有信息。关于铊及其化合物的诱变和致癌风险的数据极为稀少，但现有的数据并未表明铊具有诱变或致癌性。无论如何，即使存在此类风险，也会被铊普遍的高毒性所掩盖。另一方面，铊具有一些致畸特性，尤其是对软骨和骨骼形成方面，尽管这在雏鸡中似乎比在哺乳动物中更为明显。然而，孕妇不应接触可能产生中毒症状的铊剂量；接触较低剂量的铊，如在铊排放工厂附近可能出现的剂量，可能不会产生胚胎毒性。
