Velarde-Rodriguez Gonzalo, Belda-Para Carolina, Velasco-Ocaña Miriam, Trujillo-Sevilla Juan M, Rodríguez-Martin Javier, Jiménez-Alfaro Ignacio, Rodriguez-Ramos José M, Alejandre-Alba Nicolas
Fundación Jiménez Díaz University Hospital, Avda. Reyes Católicos, 2, Madrid, Spain.
Wooptix S.L. Avda, Trinidad 61 Planta 7, La Laguna, Tenerife, Canary Islands, Spain.
Ophthalmol Ther. 2023 Jun;12(3):1569-1582. doi: 10.1007/s40123-023-00684-2. Epub 2023 Mar 1.
This study performs optical aberration assessment in patients using a novel ultra-high-resolution device. The objective of this study is to analyze optical aberrations, especially the very high order wavefront (more than 10th order of Zernike coefficients), and compare between keratoconus and healthy patients.
In this cross-sectional study, we analyzed 43 eyes from 25 healthy patients and 43 eyes from 27 patients with keratoconus using corneal tomography and a very high-resolution (8.55 µm) aberrometer prototype (T-eyede) outfitted with a sensor originally developed for use in the field of astrophysics. Corneal aberration values were assessed using an optical model built with Zemax optical software, while ocular aberrations were assessed using T-eyede. In addition, image-processing analysis was performed of the wavefront phase, creating a high-pass filter map.
We found lower values for ocular aberrations than corneal aberrations in both groups (p < 0.001). Specifically, we found a reduction in primary astigmatism (0.145 µm) and primary coma (0.017 µm). Also, the keratoconus group showed significantly higher wavefront aberration values compared with controls (p < 0.001). An analysis of the high-pass filter map revealed 2 contrasting results: one smooth or clear, while the other presented a banding pattern. Almost all in the control group (95%) showed the first pattern, while 77% of the keratoconus group showed a banding pattern on the filtered map (chi-squared test, p < 0.001).
This device provides reliable, precise measurements of ocular aberrations that correlate well with corneal aberrations. Furthermore, the extraordinary high-resolution measurements revealed unprecedented micro changes in the wavefront phase of patients with keratoconus that varied with disease stage. These findings could lead to new screening or follow-up methods.
本研究使用一种新型超高分辨率设备对患者进行光学像差评估。本研究的目的是分析光学像差，特别是非常高阶的波前像差（泽尼克系数超过十阶），并比较圆锥角膜患者和健康患者之间的差异。
在这项横断面研究中，我们使用角膜地形图和配备了最初为天体物理学领域开发的传感器的超高分辨率（8.55微米）像差仪原型（T-eyede），分析了25名健康患者的43只眼和27名圆锥角膜患者的43只眼。使用Zemax光学软件构建的光学模型评估角膜像差值，而使用T-eyede评估眼像差。此外，对波前相位进行图像处理分析，创建高通滤波图。
我们发现两组的眼像差值均低于角膜像差值（p < 0.001）。具体而言，我们发现原发性散光（0.145微米）和原发性彗差（0.017微米）有所降低。此外，圆锥角膜组的波前像差值显著高于对照组（p < 0.001）。对高通滤波图的分析揭示了两个对比结果：一个平滑或清晰，而另一个呈现带状模式。几乎所有对照组（95%）显示第一种模式，而77%的圆锥角膜组在滤波图上显示带状模式（卡方检验，p < 0.001）。
该设备能够提供与角膜像差良好相关的可靠、精确的眼像差测量。此外，超高分辨率测量揭示了圆锥角膜患者波前相位前所未有的微观变化，这些变化随疾病阶段而变化。这些发现可能会带来新的筛查或随访方法。
