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Lactam utilisation in Aspergillus nidulans: evidence for a fourth gene under the control of the integrator gene intA.

作者信息

Arst H N, Penfold H A, Bailey C R

出版信息

Mol Gen Genet. 1978 Nov 9;166(3):321-7. doi: 10.1007/BF00267625.

DOI:10.1007/BF00267625
PMID:368580
Abstract

Mutations in the lamA gene of Aspergillus nidulans prevent the conversion of exogenous 2-pyrrolidone (gamma-butyrolactam) to gamma-amino-n-butyrate (GABA) and also prevent the (probably analogous) utilisation of 2-piperidone (sigma-valerolactam). The lamA gene, in linkage group VIII, probably specifies a lactamase but a rôle in lactam uptake cannot be ruled out. lamA is probably under the control of the positive acting regulatory gene intA, which can integrate its expression with the expression of three other genes, specifying acetamidase, GABA transaminase, and GABA permease, respectively.

摘要

相似文献

1
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2
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3
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The TamA protein fused to a DNA-binding domain can recruit AreA, the major nitrogen regulatory protein, to activate gene expression in Aspergillus nidulans.与DNA结合结构域融合的TamA蛋白可募集主要氮调节蛋白AreA，以激活构巢曲霉中的基因表达。

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