Hynes M J
J Bacteriol. 1970 Aug;103(2):482-7. doi: 10.1128/jb.103.2.482-487.1970.
Aspergillus nidulans can grow on acetamide as both a carbon and nitrogen source and can also grow on formamide as a nitrogen source. Two distinct enzymes, an acetamidase and a formamidase, are produced. The control of the synthesis of these two enzymes in a wild-type strain was investigated. The formamidase is induced by acetamide and formamide and repressed by ammonia. The acetamidase is induced by formamide and acetamide, repressed by carbon metabolites derived from glucose and acetate, and repressed by ammonia. Repression of the acetamidase by ammonia depends on the carbon source; growth on glucose but not on acetate or acetamide allows repression to occur. The pattern of acetamidase repression is compared with that of histidine catabolic enzymes in various bacteria.
构巢曲霉能够以乙酰胺作为碳源和氮源生长，也能够以甲酰胺作为氮源生长。它会产生两种不同的酶，一种是乙酰胺酶，另一种是甲酰胺酶。对野生型菌株中这两种酶的合成调控进行了研究。甲酰胺酶由乙酰胺和甲酰胺诱导产生，并受到氨的抑制。乙酰胺酶由甲酰胺和乙酰胺诱导产生，受到源自葡萄糖和乙酸盐的碳代谢物的抑制，也受到氨的抑制。氨对乙酰胺酶的抑制作用取决于碳源；在葡萄糖上生长而非在乙酸盐或乙酰胺上生长时，才会发生抑制作用。将乙酰胺酶的抑制模式与各种细菌中组氨酸分解代谢酶的抑制模式进行了比较。
