Laboratory of Pharmacology, Faculty of Medicine of Sfax, University of Sfax, Majida Boulila Avenue, 3029, Sfax, Tunisia.
Laboratories of Histology and Embryology, Faculty of Medicine of Sfax, University of Sfax, Sfax, Tunisia.
Arch Dermatol Res. 2023 Sep;315(7):1945-1952. doi: 10.1007/s00403-023-02572-y. Epub 2023 Mar 1.
Heliotropium europaeum has been traditionally used to stop bleeding and accelerate scarring. This study provides a scientific evaluation of H. europaeum haemostatic and healing potential. To evaluate the haemostatic effect of H. europaeum, the time of bleeding of fresh wounds induced experimentally in rats was studied. Excision wounds were induced upon four groups; each one contains six rats to estimate the healing properties of wounds. Group 1 was assigned as control (not treated), group 2 was daily treated with H. europaeum leaf powder, group 3 was treated with H. europaeum every 6 days and group 4 was treated with a reference drug, an emulsion containing 10% of Mimosa tenuiflora extract. All the parameters were significantly tested (p < 0.05) with comparison to a group control. The use of H. europaeum significantly shortened the bleeding time. The rats which were daily treated with H. europaeum healed in 12 days. This time period was significantly shorter than the control groups. Wound excision was uniformly induced randomly on the dorsum of rats in 4 groups (tested support and control). The post-healing biopsies were histologically assessed, revealed a better healing quality, and continued complete tissue regeneration, abundant and well-organized network of collagen fibres, and low numbers of inflammatory cells. The experimental data revealed that H. europaeum displayed remarkable haemostatic and wound healing activities.
欧洲千里光传统上被用于止血和加速愈合。本研究对欧洲千里光的止血和愈合潜力进行了科学评价。为了评估欧洲千里光的止血作用，研究了在实验中诱导的新鲜伤口的出血时间。在四个组中诱导切除伤口；每组包含六只老鼠，以评估伤口的愈合特性。第 1 组为对照组（未治疗），第 2 组每天用欧洲千里光叶粉治疗，第 3 组每 6 天用欧洲千里光治疗，第 4 组用参考药物，即含有 10%金合欢提取物的乳剂治疗。所有参数均与对照组相比均具有显著意义（p<0.05）。使用欧洲千里光可显著缩短出血时间。每天用欧洲千里光治疗的大鼠在 12 天内愈合。这一时间明显短于对照组。在四个组（测试支持组和对照组）的背部随机均匀地诱导伤口切除。对愈合后的活检进行组织学评估，结果显示愈合质量更好，持续完全的组织再生，丰富且组织良好的胶原纤维网络，以及较少的炎症细胞。实验数据表明，欧洲千里光具有显著的止血和愈合作用。
