• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

抗炎、抗癌（MCF-7、3T3 和 HeLa 细胞系）以及提取物和全植物馏分的卤虫致死试验和傅里叶变换红外光谱分析。

Anti-Inflammatory, Anticancer (MCF-7, 3T3, and HeLa Cell Lines), and Brine Shrimp Lethality Assay and FTIR Analysis of the Extract and Fractions of the Whole Plant of .

机构信息

Institute of Biochemistry, University of Balochistan, Quetta 87300, Pakistan.

Department of Botany, University of Balochistan, Quetta 87300, Pakistan.

出版信息

Mediators Inflamm. 2020 Feb 1;2020:5056897. doi: 10.1155/2020/5056897. eCollection 2020.

DOI:10.1155/2020/5056897
PMID:32076387
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7016474/
Abstract

In this study, anti-inflammatory, anticancer, brine shrimp lethality, and FTIR studies were evaluated. The oxidative burst assay using the chemiluminescence technique, MTT assay, brine shrimp lethality assay, and FTIR analysis were the methods used for the evaluation of anti-inflammatory, anticancer, brine shrimp lethality, and FTIR studies, respectively. The whole-plant butanol fraction of (WBFHE) showed anti-inflammatory activity on ROS having IC14.7 ± 2.5 while the extract and other fractions of the whole plant of exhibited no anti-inflammatory activity. None of the extract and fractions of the whole plant of exhibited anticancer (MCF-7, 3T3, and HeLa cell lines) activities. The whole-plant aqueous fraction of (WAFHE) and whole-plant butanol fraction of (WBFHE) showed lethality at high concentration while at low concentration, no toxicity was shown. The whole-plant methanolic extract of (WMEHE) and whole-plant n-hexane fraction of (WHFHE) exhibited no toxicity. FTIR interpretation showed the functional groups for the aromatic compounds, phenols, carboxylic acids, esters, alkanes, alkenes, alcohols, alkyl halides, sulfate esters, phosphines, silanes, nitriles, thiols, amines, phosphoric acids, and nitro compounds.

摘要

在这项研究中，评估了抗炎、抗癌、卤虫致死和 FTIR 研究。使用化学发光技术评估氧化爆发测定法、MTT 测定法、卤虫致死测定法和 FTIR 分析，分别用于抗炎、抗癌、卤虫致死和 FTIR 研究的评估。（WBFHE）的全植物正丁醇级分显示对 ROS 具有抗炎活性，IC14.7±2.5，而全植物提取物和其他级分则没有抗炎活性。全植物的提取物和级分均没有显示出抗癌（MCF-7、3T3 和 HeLa 细胞系）活性。（WAFHE）的全植物水级分和（WBFHE）的全植物正丁醇级分在高浓度时表现出致死性，而在低浓度时则没有显示出毒性。（WMEHE）的全植物甲醇提取物和（WHFHE）的全植物正己烷级分没有显示出毒性。FTIR 解释表明存在芳香族化合物、酚类、羧酸、酯类、烷烃、烯烃、醇类、烷基卤化物、硫酸盐酯类、膦类、硅烷类、腈类、硫醇类、胺类、磷酸和硝基化合物的功能基团。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/000f/7016474/66dedf159c24/MI2020-5056897.012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/000f/7016474/0ac2584742ca/MI2020-5056897.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/000f/7016474/3f5211e73445/MI2020-5056897.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/000f/7016474/9c8dd18e4810/MI2020-5056897.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/000f/7016474/06a4f6785ea4/MI2020-5056897.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/000f/7016474/f133262dad69/MI2020-5056897.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/000f/7016474/f2ddc8304dde/MI2020-5056897.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/000f/7016474/9f4b2dca7621/MI2020-5056897.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/000f/7016474/394e0714cbb0/MI2020-5056897.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/000f/7016474/9bf13e1df112/MI2020-5056897.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/000f/7016474/b9c80cd3a512/MI2020-5056897.010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/000f/7016474/7a56f42b04d4/MI2020-5056897.011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/000f/7016474/66dedf159c24/MI2020-5056897.012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/000f/7016474/0ac2584742ca/MI2020-5056897.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/000f/7016474/3f5211e73445/MI2020-5056897.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/000f/7016474/9c8dd18e4810/MI2020-5056897.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/000f/7016474/06a4f6785ea4/MI2020-5056897.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/000f/7016474/f133262dad69/MI2020-5056897.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/000f/7016474/f2ddc8304dde/MI2020-5056897.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/000f/7016474/9f4b2dca7621/MI2020-5056897.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/000f/7016474/394e0714cbb0/MI2020-5056897.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/000f/7016474/9bf13e1df112/MI2020-5056897.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/000f/7016474/b9c80cd3a512/MI2020-5056897.010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/000f/7016474/7a56f42b04d4/MI2020-5056897.011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/000f/7016474/66dedf159c24/MI2020-5056897.012.jpg

相似文献

1
Anti-Inflammatory, Anticancer (MCF-7, 3T3, and HeLa Cell Lines), and Brine Shrimp Lethality Assay and FTIR Analysis of the Extract and Fractions of the Whole Plant of .抗炎、抗癌（MCF-7、3T3 和 HeLa 细胞系）以及提取物和全植物馏分的卤虫致死试验和傅里叶变换红外光谱分析。
Mediators Inflamm. 2020 Feb 1;2020:5056897. doi: 10.1155/2020/5056897. eCollection 2020.
2
In Vitro Anticancer MCF-7, Anti-Inflammatory, and Brine Shrimp Lethality Assay (BSLA) and GC-MS Analysis of Whole Plant Butanol Fraction of (WBFRR).（WBFRR）全植物正丁醇部位的体外抗癌 MCF-7、抗炎和卤虫致死试验（BSLA）及 GC-MS 分析。
Biomed Res Int. 2019 Jun 23;2019:3264846. doi: 10.1155/2019/3264846. eCollection 2019.
3
Cytotoxic and phytotoxic actions of Heliotropium strigosum.硬毛天芥菜的细胞毒性和植物毒性作用。
Toxicol Ind Health. 2015 May;31(5):429-32. doi: 10.1177/0748233712471706. Epub 2013 Feb 13.
4
CYTOTOXIC, α-CHYMOTRYPSIN AND UREASE INHIBITION ACTIVITIES OF THE PLANT L.植物L的细胞毒性、α-胰凝乳蛋白酶和脲酶抑制活性
Afr J Tradit Complement Altern Med. 2016 Sep 29;13(6):194-198. doi: 10.21010/ajtcam.v13i6.28. eCollection 2016.
5
In Vitro Antimicrobial Bioassays, DPPH Radical Scavenging Activity, and FTIR Spectroscopy Analysis of Heliotropium bacciferum.浆果天芥菜的体外抗菌生物测定、DPPH自由基清除活性及傅里叶变换红外光谱分析
Biomed Res Int. 2016;2016:3818945. doi: 10.1155/2016/3818945. Epub 2016 Aug 11.
6
In-vitro bioassays of aqueous and ethanol extracts of Aseel dates.阿塞拜疆种鸡的水提物和醇提物的体外生物测定
Pak J Pharm Sci. 2020 Jul;33(4):1623-1629.
7
Anticancer and antimicrobial activity of biosynthesized Red Sea marine algal silver nanoparticles.海洋藻类生物合成银纳米粒子的抗癌和抗菌活性。
Sci Rep. 2022 Feb 14;12(1):2421. doi: 10.1038/s41598-022-06412-3.
8
Phytochemical analysis, antioxidant, anticancer and anti-inflammatory activities of fruits.水果的植物化学分析、抗氧化、抗癌和抗炎活性
Int J Environ Health Res. 2023 Dec;33(12):1676-1685. doi: 10.1080/09603123.2022.2115469. Epub 2022 Aug 24.
9
Oliveria decumbens Vent. (Apiaceae): Biological screening and chemical compositions.垂序山黧豆（伞形科）：生物筛选和化学成分。
J Ethnopharmacol. 2024 Jan 10;318(Pt B):117053. doi: 10.1016/j.jep.2023.117053. Epub 2023 Aug 16.
10
Preliminary evaluation of haemostatic and wound healing potential of Heliotropium europaeum.颠茄叶止血和促进伤口愈合潜力的初步评价。
Arch Dermatol Res. 2023 Sep;315(7):1945-1952. doi: 10.1007/s00403-023-02572-y. Epub 2023 Mar 1.

引用本文的文献

1
QSAR, molecular docking, MD simulations, and ADMET screening identify potential leads against key targets in benign prostatic hyperplasia.定量构效关系（QSAR）、分子对接、分子动力学（MD）模拟以及药物代谢动力学/药物毒性（ADMET）筛选确定了针对良性前列腺增生关键靶点的潜在先导化合物。
In Silico Pharmacol. 2024 Nov 19;12(2):107. doi: 10.1007/s40203-024-00280-7. eCollection 2024.
2
Synthesis of 1,2,3,triazole modified analogues of hydrochlorothiazide via click chemistry approach and in-vitro α-glucosidase enzyme inhibition studies.通过点击化学方法合成 1,2,3-三唑修饰的氢氯噻嗪类似物及其体外α-葡萄糖苷酶抑制活性研究。
Mol Divers. 2022 Aug;26(4):2049-2067. doi: 10.1007/s11030-021-10314-3. Epub 2021 Oct 4.

本文引用的文献

1
In Vitro Anticancer MCF-7, Anti-Inflammatory, and Brine Shrimp Lethality Assay (BSLA) and GC-MS Analysis of Whole Plant Butanol Fraction of (WBFRR).（WBFRR）全植物正丁醇部位的体外抗癌 MCF-7、抗炎和卤虫致死试验（BSLA）及 GC-MS 分析。
Biomed Res Int. 2019 Jun 23;2019:3264846. doi: 10.1155/2019/3264846. eCollection 2019.
2
The diagnosis and treatment of a symptomatic mesenteric cyst.有症状的肠系膜囊肿的诊断与治疗
BMJ Case Rep. 2014 May 8;2014:bcr2013202410. doi: 10.1136/bcr-2013-202410.
3
In Vitro antimicrobial activity of Allium cepa (dry bulbs) against Gram positive and Gram negative bacteria and fungi.
洋葱（干鳞茎）对革兰氏阳性菌、革兰氏阴性菌和真菌的体外抗菌活性。
Pak J Pharm Sci. 2014 Jan;27(1):139-45.
4
Direct detection of triterpenoid saponins in medicinal plants.药用植物中三萜皂苷的直接检测
Afr J Tradit Complement Altern Med. 2007 Oct 27;5(1):56-60. doi: 10.4314/ajtcam.v5i1.31257.
5
Biological screening of Brazilian medicinal plants.巴西药用植物的生物学筛选。
Mem Inst Oswaldo Cruz. 2000 May-Jun;95(3):367-73. doi: 10.1590/s0074-02762000000300012.
6
Chemiluminescence response of human natural killer cells. I. The relationship between target cell binding, chemiluminescence, and cytolysis.人类自然杀伤细胞的化学发光反应。I. 靶细胞结合、化学发光与细胞溶解之间的关系。
J Exp Med. 1982 Aug 1;156(2):492-505. doi: 10.1084/jem.156.2.492.
7
Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines.使用人类及其他肿瘤细胞系评估一种用于培养中细胞生长和药物敏感性的可溶性四氮唑/甲臜检测法。
Cancer Res. 1988 Sep 1;48(17):4827-33.