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女性尿道背侧黏膜瓣颊黏膜移植尿道成形术:单中心经验。

Female urethroplasty with dorsal onlay buccal mucosal graft: a single institution experience.

机构信息

Division of Urology, University of Colorado Anschutz Medical Campus, 12631 East 17th Avenue, C-319, Aurora, CO, 80045, USA.

出版信息

Int Urol Nephrol. 2023 May;55(5):1149-1154. doi: 10.1007/s11255-023-03520-5. Epub 2023 Mar 1.

Abstract

PURPOSE

Female urethral stricture disease is frequently unrecognized or misdiagnosed, with controversy in the literature regarding the definition of strictures and approach to management. The purpose of this study is to report our institutional experience with female urethroplasty and add our experience to the growing body of research.

METHODS

We performed a retrospective review of patients undergoing female urethroplasty with dorsal onlay BMG at the University of Colorado between March 2015 and December 2021 performed by two surgeons (BF and JO). The primary outcome measure was surgical success, defined as no stricture recurrence. The secondary outcome measure was the incidence of de novo urinary incontinence.

RESULTS

23 patients were included in our data analysis. The median duration of lower urinary tract symptoms prior to urethroplasty was 16 years. 87% had undergone previous dilations. At a median follow-up of 12.2 months (range 1-81 months), four patients required a secondary procedure for obstruction with an overall success rate of 83%. One patient developed de novo stress urinary incontinence and one patient developed urge urinary incontinence. Subgroup analysis was performed comparing the patients that developed stricture recurrence (N = 4) to those that did not (N = 19). Those with stricture recurrence had a longer duration of symptoms and more dilations prior to urethroplasty.

CONCLUSION

Female urethroplasty with BMG is effective at treating female urethral stricture disease, with excellent outcomes at over a year of follow-up and minimal risk of stress incontinence postoperatively.

摘要

目的

女性尿道狭窄疾病经常被忽视或误诊,文献中对于狭窄的定义和处理方法存在争议。本研究旨在报告我们机构在女性尿道成形术中的经验,并为不断增加的研究提供我们的经验。

方法

我们对 2015 年 3 月至 2021 年 12 月期间由两位外科医生(BF 和 JO)在科罗拉多大学进行的采用背侧镶嵌移植物(BMG)的女性尿道成形术患者进行了回顾性研究。主要结局测量指标是手术成功,定义为无狭窄复发。次要结局测量指标是新发尿失禁的发生率。

结果

我们的数据分析纳入了 23 名患者。尿道成形术前下尿路症状的中位持续时间为 16 年。87%的患者曾接受过扩张治疗。中位随访时间为 12.2 个月(范围 1-81 个月),4 名患者因梗阻需要二次手术,总体成功率为 83%。1 名患者新发压力性尿失禁,1 名患者新发急迫性尿失禁。我们对发生狭窄复发的患者(N=4)和未发生狭窄复发的患者(N=19)进行了亚组分析。复发狭窄的患者症状持续时间更长,尿道成形术前接受的扩张治疗更多。

结论

采用 BMG 的女性尿道成形术治疗女性尿道狭窄疾病有效,在超过 1 年的随访中效果良好,术后发生压力性尿失禁的风险极小。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11b5/10105657/ef696ca1de3d/11255_2023_3520_Fig1_HTML.jpg

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