Lycored Ltd, Beersheva, Israel.
Lycored Corp, Branchburg, New Jersey, USA.
J Cosmet Dermatol. 2023 Jun;22(6):1786-1798. doi: 10.1111/jocd.15650. Epub 2023 Mar 1.
Healthy and a youthful appearance is a common desire of the aging population. "Beauty from within" involves using nutrition and nutraceuticals to support skin function for reducing and reversing signs of aging such as wrinkles, pigmentary changes, skin laxity, and dullness. Carotenoids possess strong antioxidant and anti-inflammatory activities and are effective in improving skin barrier and could thereby stimulate "beauty from within" by providing endogenous support to reduce the expressions of aging.
This study was designed to determine whether 3-month supplementation with Lycomato would improve skin condition.
A panel of 50 female subjects used Lycomato capsules as nutritional supplements for 3 months. Skin status was observed via questionnaires for the assessment of skin condition and expert visual grading of facial markers such as wrinkles, tonality, roughness, laxity, and pore size. Skin barrier was assessed using transepidermal water loss (TEWL). Measurements were obtained before treatment and after 4 and 12 weeks of use.
Results indicated a statistically significant improvement (p < 0.05) in skin barrier as measured by TEWL after 12 weeks of consuming the supplement. There was also a significant improvement in skin tonality, lines and wrinkles, pore size, and skin firmness as observed by expert evaluation as well as subject self-assessment.
Based on the confines and conditions of this study, oral supplementation with Lycomato resulted in significant improvement in skin barrier. Visual appearance of lines and wrinkles, skin tonality, pores, smoothness, and firmness were considerably improved, and these improvements were found to be substantially discernible by the subjects.
健康和年轻的外表是老龄化人口的共同愿望。“内在美”涉及使用营养和营养保健品来支持皮肤功能，以减少和逆转衰老迹象，如皱纹、色素变化、皮肤松弛和无光泽。类胡萝卜素具有强大的抗氧化和抗炎活性，可有效改善皮肤屏障功能，从而通过提供内源性支持来减少衰老的表达，从而刺激“内在美”。
本研究旨在确定 3 个月的 Lycomato 补充剂是否能改善皮肤状况。
一组 50 名女性受试者使用 Lycomato 胶囊作为营养补充剂，连续补充 3 个月。通过皮肤状况问卷评估皮肤状况，并通过专家对面部标记（如皱纹、色调、粗糙度、松弛度和毛孔大小）的视觉分级来评估皮肤状况。使用经表皮水分流失（TEWL）评估皮肤屏障。在治疗前、使用 4 周和 12 周后进行测量。
结果表明，在补充 12 周后，TEWL 测量的皮肤屏障有统计学意义的改善（p<0.05）。通过专家评估和受试者自我评估，皮肤色调、线条和皱纹、毛孔大小和皮肤紧致度也有显著改善。
根据本研究的限制和条件，口服 Lycomato 补充剂可显著改善皮肤屏障。线条和皱纹、皮肤色调、毛孔、光滑度和紧致度的外观得到了极大的改善，这些改善被受试者明显察觉。
