Lycored Ltd, Beer Sheva, Israel.
Lycored CORP, Secaucus, New Jersey, USA.
Skin Res Technol. 2023 Nov;29(11):e13504. doi: 10.1111/srt.13504.
Improvement of skin barrier strength could lead to healthy and youthful appearance. "Beauty inside-out" approach using nutraceuticals such as tomato derived carotenoids to support skin barrier strength could be of benefit to the ageing population.
A panel of 60 female subjects were provided with the Lumenato capsules (containing carotenoids) or placebo capsules as nutritional supplements for 3 months. Skin health and barrier function were observed using evaporimeter which measures trans epidermal water loss (TEWL). Barrier strength was determined by study of the number of strippings required to disrupt skin barrier and barrier repair was observed in terms of TEWL a few hours after barrier disruption. Cutometer was used to observe skin firmness and elasticity. Measurements were obtained before treatment and after 4 and 12 weeks of use.
Results indicated a statistically significant improvement (p < 0.05) in skin barrier strength; a higher number of strippings were required to disrupt skin barrier after 12 weeks of supplement use. There was also a significant improvement in skin firmness and elasticity as observed with a cutometer.
Based on the confines and conditions of this study, oral supplementation with Lumenato resulted in significant improvement in skin barrier as well as skin firmness and elasticity.
改善皮肤屏障强度可带来健康年轻的外观。使用类胡萝卜素等营养保健品的“内调外养”方法来增强皮肤屏障，可能对老年人群有益。
一组 60 名女性受试者被提供 Lumenato 胶囊（含类胡萝卜素）或安慰剂胶囊作为营养补充剂，连续服用 3 个月。使用蒸发计测量经表皮水分流失（TEWL）来观察皮肤健康和屏障功能。通过研究破坏皮肤屏障所需的剥离次数来确定屏障强度，并在破坏屏障数小时后观察 TEWL 以评估屏障修复情况。使用皮肤弹性测试仪测量皮肤的紧实度和弹性。在治疗前以及使用 4 周和 12 周后进行测量。
结果表明，皮肤屏障强度有统计学意义的显著改善（p<0.05）；补充 12 周后，需要更多的剥离次数才能破坏皮肤屏障。使用皮肤弹性测试仪也观察到皮肤紧实度和弹性有显著改善。
基于本研究的限制和条件，口服补充 Lumenato 可显著改善皮肤屏障以及皮肤的紧实度和弹性。
