Xu Guangcan, Hou Baoke, Xue Cuiping, Xu Quangang, Qu Linghui, Hao Xiaolu, Liu Ying, Wang Dajiang, Li Zhaohui, Jin Xin
Senior Department of Ophthalmology, The Third Medical Center of PLA General Hospital, Beijing, China.
School of Medicine, Nankai University, Tianjin, China.
Ocul Immunol Inflamm. 2024 Jul;32(5):594-601. doi: 10.1080/09273948.2023.2181188. Epub 2023 Mar 2.
To analyze a case of acute retinal necrosis (ARN) associated with pseudorabies virus (PRV) infection and discusses the clinical characteristics of PRV-induced ARN (PRV-ARN).
Case report and literature review of ocular features in PRV-ARN.
A 52-year-old female diagnosed with encephalitis presented with bilateral vision loss, mild anterior uveitis, vitreous opacity, occlusive retinal vasculitis, and retinal detachment in her left eye. The result of metagenomic next-generation sequencing (mNGS) indicated that both cerebrospinal fluids and vitreous fluid tested positive for PRV.
PRV, a zoonosis, can infect both humans and mammals. Patients affected with PRV may experience severe encephalitis and oculopathy, and the infection has been associated with high mortality and disability. ARN is the most common ocular disease, which develops rapidly following encephalitis and is characterized by five figures: bilateral onset, rapid progression, severe visual impairment, poor response to systemic antiviral drugs, and an unfavorable prognosis.
分析1例与伪狂犬病病毒（PRV）感染相关的急性视网膜坏死（ARN）病例，并探讨PRV诱导的ARN（PRV-ARN）的临床特征。
对PRV-ARN眼部特征进行病例报告及文献复习。
1例52岁诊断为脑炎的女性患者出现双侧视力丧失，轻度前葡萄膜炎，玻璃体混浊，视网膜血管闭塞性炎症及左眼视网膜脱离。宏基因组下一代测序（mNGS）结果显示脑脊液和玻璃体液PRV检测均为阳性。
PRV为人畜共患病原，可感染人类和哺乳动物。感染PRV的患者可能出现严重的脑炎和眼部病变，且该感染与高死亡率和残疾相关。ARN是最常见的眼部疾病，在脑炎后迅速发展，具有双侧发病、进展迅速、严重视力损害、全身抗病毒药物反应差及预后不良这五大特征。
