Department of Ophthalmology, Qilu Hospital of Shandong University, Shandong University, 107 West Wenhua Road, Lixia District, Jinan, Shandong 250012, PR China; Shandong University Cheeloo College of Medicine, 44 West Wenhua Road, Lixia District, Jinan, Shandong 250012, PR China.
Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Medical University Eye Hospital, School of Optometry and Ophthalmology & Eye Institute, No. 251 Fu Kang Road, Nankai District, Tianjin 300384, PR China.
Int J Infect Dis. 2019 Dec;89:51-54. doi: 10.1016/j.ijid.2019.09.019. Epub 2019 Sep 25.
We report the case of a patient who presented with viral encephalitis and a pulmonary infection complicated with bilateral acute retinal necrosis after direct contact with diseased swine. Next-generation sequencing of the cerebrospinal fluid and vitreous humor detected pseudorabies virus (PRV) simultaneously. Intravenous acyclovir and dexamethasone treatment improved the symptoms of encephalitis, and vitrectomy surgery with silicone oil tamponade was used to treat the retinal detachment. This case implies that PRV can infect humans; thus, self-protection is imperative when there is contact with animals.
我们报告了一例患者，他因直接接触病猪而出现病毒性脑炎和肺部感染合并双侧急性视网膜坏死。对脑脊液和玻璃体进行下一代测序同时检测到伪狂犬病病毒 (PRV)。静脉注射阿昔洛韦和地塞米松治疗改善了脑炎症状，而玻璃体切除术联合硅油填塞用于治疗视网膜脱离。该病例表明 PRV 可以感染人类；因此，与动物接触时必须进行自我保护。
