Sinclair B L, Clark D W, Sears M R
Department of Pharmacology, University of Otago Medical School, Dunedin, New Zealand.
Thorax. 1987 Sep;42(9):670-5. doi: 10.1136/thx.42.9.670.
Increased sales of anti-asthma drugs, and a second "epidemic" of asthma mortality, raised concerns about the management of asthma in New Zealand. To study this, prescriptions were obtained from randomly selected pharmacies to identify 235 patients receiving one common anti-asthma drug, 175 of whom were willing to be interviewed. The authors considered that 80% had asthma, and only 20% suffered primarily from chronic bronchitis or emphysema. The increased sales of anti-asthma drugs could not therefore be explained by their increasing use in treatment of other respiratory disorders. One third of the identified asthmatic subjects experienced daily symptoms despite regular drug treatment. Inhaled corticosteroids were used by only 42% of this group with persistent symptoms. Regular or short course oral corticosteroids, with or without inhaled steroids, had been required by 49%. All patients with domiciliary nebulisers appeared to use these appropriately, and most had peak expiratory flow meters. Despite the increased sales of anti-asthma drugs, corticosteroids appear to be as much underused in patients with chronic asthma in the community as in those who die of their disease.
抗哮喘药物销量的增加以及哮喘死亡率的第二次“流行”,引发了对新西兰哮喘管理的担忧。为了对此进行研究,从随机挑选的药店获取了处方,以确定235名正在使用一种常见抗哮喘药物的患者,其中175人愿意接受访谈。作者认为80%的患者患有哮喘,只有20%主要患有慢性支气管炎或肺气肿。因此,抗哮喘药物销量的增加不能用其在治疗其他呼吸系统疾病中的使用增加来解释。三分之一已确诊的哮喘患者尽管接受了常规药物治疗,但仍有日常症状。在有持续症状的这组患者中,只有42%使用吸入性糖皮质激素。49%的患者需要定期或短期口服糖皮质激素,无论是否联合吸入性糖皮质激素。所有配备家用雾化器的患者似乎都能正确使用,且大多数人有呼气峰值流速仪。尽管抗哮喘药物销量增加,但在社区慢性哮喘患者中,糖皮质激素的使用不足情况似乎与死于该疾病的患者一样严重。