Mahajan Rahul, Raj Dinesh, De Dipankar, Handa Sanjeev
Department of Dermatology, Venereology, and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Indian J Dermatol. 2022 Sep-Oct;67(5):531-534. doi: 10.4103/ijd.ijd_100_22.
Few studies have shown an association between adult lichen planus and dyslipidemia, but none has shown an association with the pediatric population. We planned to study the association between pediatric lichen planus and metabolic syndrome (MS).
This is a single-centre, cross-sectional, case-control study from July 2018 to December 2019 at a tertiary care institute. Twenty children in the age group of 6-16 years, diagnosed as cases of childhood/adolescent lichen planus, and 40 age- and sex-matched controls were included in this study and evaluated for metabolic syndrome.Patients' anthropometry including weight, height, waist circumference, and body mass index (BMI) was recorded. Blood samples were sent for the measurement of fasting plasma glucose, high-density lipoprotein (HDL), low-density lipoprotein (LDL) cholesterol, and triglyceride levels.
The mean HDL was found to be significantly lower in children with lichen planus compared to children without lichen planus ( = 0.012), although there was no statistically significant difference in the frequency of patients having deranged HDL levels between the groups ( = 0.326). Children with lichen planus had a higher prevalence of central obesity, but the difference was not statistically significant ( = 0.101). There was no significant difference between mean BMI, hypertension, triglyceride, LDL, and fasting blood sugar values between the groups. Using the logistic regression analysis model, it was found that the strongest independent variable that impacts the occurrence of lichen planus was an HDL value less than 40 mg/dl ( = 0.017; OR 1.02 to 1.29).
This study shows an association between paediatric lichen planus and dyslipidemia.
很少有研究表明成人扁平苔藓与血脂异常之间存在关联，但尚无研究表明其与儿童群体有关联。我们计划研究儿童扁平苔藓与代谢综合征（MS）之间的关联。
这是一项于2018年7月至2019年12月在一家三级医疗机构进行的单中心、横断面病例对照研究。本研究纳入了20名年龄在6至16岁、被诊断为儿童期/青少年扁平苔藓的儿童，以及40名年龄和性别匹配的对照，并对其进行代谢综合征评估。记录患者的人体测量数据，包括体重、身高、腰围和体重指数（BMI）。采集血样以测量空腹血糖、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）胆固醇和甘油三酯水平。
与无扁平苔藓的儿童相比，扁平苔藓患儿的平均HDL水平显著降低（P = 0.012），尽管两组间HDL水平异常的患者频率无统计学显著差异（P = 0.326）。扁平苔藓患儿中心性肥胖的患病率较高，但差异无统计学意义（P = 0.101）。两组间平均BMI、高血压、甘油三酯、LDL和空腹血糖值无显著差异。使用逻辑回归分析模型发现，影响扁平苔藓发生的最强独立变量是HDL值低于40mg/dl（P = 0.017；OR为1.02至1.29）。
本研究表明儿童扁平苔藓与血脂异常之间存在关联。
