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扁平苔藓与代谢综合征：存在关联吗？

Lichen Planus and Metabolic Syndrome: Is There a Relation?

作者信息

Singla Rohit, Ashwini P K, Jayadev Betkerur

机构信息

Department of Dermatology and Venereology, JSS Medical College, JSS Academy of Higher Education and Research, Mysore, Karnataka, India.

Department of Dermatology and Venereology, Maharishi Markandeshwar Institute of Medical Sciences and Research, Mullana, Ambala, Haryana, India.

出版信息

Indian Dermatol Online J. 2019 Aug 28;10(5):555-559. doi: 10.4103/idoj.IDOJ_499_18. eCollection 2019 Sep-Oct.

DOI:10.4103/idoj.IDOJ_499_18
PMID:31544075
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6743384/
Abstract

BACKGROUND

Recent data suggests association of lichen planus (LP) with various systemic disorders. Relationship between LP and metabolic syndrome (MS) is not yet taken into account. MS has been associated with increased risk of cardiovascular diseases. Hence, earlier detection and treatment could potentially decrease mortality and improve the quality of life in these patients.

OBJECTIVES

To find out the association of LP with MS.

MATERIALS AND METHODS

About 100 LP patients and 50 healthy adults were investigated for fasting blood glucose (FBS) and lipid profile. MS was diagnosed as per National Cholesterol Education Program's Adult Treatment Panel III guidelines.

RESULTS

Serum cholesterol, triglycerides, low density lipoprotein (LDL-C), and very low density lipoprotein (VLDL-C) values were significantly increased in cases as compared to controls ( < 0.05 in all). About 42% of patients showed raised FBS level as compared to 10% controls ( = 0.0003). MS was more prevalent in cases than in controls (43% versus 26% respectively, = 0.045). Odds ratio was highest in FBS and waist circumference.

LIMITATIONS

As the cases and controls are included from a local area, the result may differ from other parts of the world.

CONCLUSION

Diabetes mellitus, dyslipidemia, and MS are seen more commonly in LP patients.

摘要

背景

近期数据表明扁平苔藓（LP）与多种全身性疾病有关。LP与代谢综合征（MS）之间的关系尚未得到考虑。MS与心血管疾病风险增加有关。因此，早期检测和治疗可能会降低这些患者的死亡率并改善生活质量。

目的

探讨LP与MS之间的关联。

材料与方法

对约100例LP患者和50名健康成年人进行空腹血糖（FBS）和血脂谱检测。根据美国国家胆固醇教育计划成人治疗小组III指南诊断MS。

结果

与对照组相比，病例组的血清胆固醇、甘油三酯、低密度脂蛋白（LDL-C）和极低密度脂蛋白（VLDL-C）值显著升高（均P<0.05）。约42%的患者FBS水平升高，而对照组为10%（P = 0.0003）。MS在病例组中的患病率高于对照组（分别为43%和26%，P = 0.045）。FBS和腰围的比值比最高。

局限性

由于病例组和对照组来自当地，结果可能与世界其他地区不同。

结论

糖尿病、血脂异常和MS在LP患者中更为常见。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/640f/6743384/b204f6bafd39/IDOJ-10-555-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/640f/6743384/29bab15049be/IDOJ-10-555-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/640f/6743384/3420debba391/IDOJ-10-555-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/640f/6743384/7969f8e2c7ba/IDOJ-10-555-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/640f/6743384/b204f6bafd39/IDOJ-10-555-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/640f/6743384/29bab15049be/IDOJ-10-555-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/640f/6743384/3420debba391/IDOJ-10-555-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/640f/6743384/7969f8e2c7ba/IDOJ-10-555-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/640f/6743384/b204f6bafd39/IDOJ-10-555-g004.jpg

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2
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3
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