Hooshyarfard Amirarsalan, Poormoradi Banafsheh, Olad Fatemeh, Shahbazi Armaghan, Cheraghi Zahra
Dental Materials Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Department of Periodontics, Faculty of Dentistry, Shahed University, Tehran, Iran.
Front Dent. 2022 Sep 10;19:30. doi: 10.18502/fid.v19i30.10802. eCollection 2022.
Considering the side effects of chlorhexidine (CHX), which is currently the gold-standard antimicrobial mouthwash, this study aimed to compare the effects of Green Kemphor and CHX mouthwashes on tooth staining and gingivitis. This randomized controlled crossover clinical trial evaluated 38 patients requiring CHX mouthwash following oral surgery and periodontal therapy. The patients were randomly assigned to CHX and Kemphor groups (n=19). In CHX group, patients used CHX mouthwash in the first 2 weeks, and after a 4-day washout period, they used Kemphor mouthwash for 2 weeks. This order was reverse in the Kemphor group. Gingivitis was evaluated using the Silness and Loe gingival index (GI), and tooth staining was evaluated by the Lobene index at 0 (baseline), 2 and 4 weeks. Data were analyzed by paired t-test. CHX mouthwash significantly decreased the GI and increased tooth staining (gingival stains, body stains, and stain extent) at 2 weeks (P<0.05). Kemphor mouthwash significantly decreased the GI and increased tooth staining after 2 weeks (P<0.05). The GI in Kemphor group was significantly lower than that in CHX group at 4 weeks (P<0.05). Also, the tooth staining parameters in the Kemphor group were significantly lower than the corresponding values in the CHX group at 2 and 4 weeks (P<0.05). Kemphor had higher efficacy for reduction of GI and caused less tooth staining than CHX; thus, it may be recommended for use as an alternative to CHX.
考虑到目前作为金标准抗菌漱口水的洗必泰（CHX）的副作用，本研究旨在比较绿樟和CHX漱口水对牙齿染色和牙龈炎的影响。这项随机对照交叉临床试验评估了38例口腔手术和牙周治疗后需要使用CHX漱口水的患者。患者被随机分为CHX组和樟组（n = 19）。在CHX组中，患者在最初2周使用CHX漱口水，经过4天的洗脱期后，他们使用樟漱口水2周。在樟组中顺序相反。使用Silness和Loe牙龈指数（GI）评估牙龈炎，并在0周（基线）、2周和4周时通过Lobene指数评估牙齿染色情况。数据采用配对t检验进行分析。CHX漱口水在2周时显著降低了GI并增加了牙齿染色（牙龈染色、牙体染色和染色范围）（P<0.05）。樟漱口水在2周后显著降低了GI并增加了牙齿染色（P<0.05）。在4周时，樟组的GI显著低于CHX组（P<0.05）。此外，在2周和4周时，樟组的牙齿染色参数显著低于CHX组的相应值（P<0.05）。与CHX相比，樟在降低GI方面具有更高的疗效，并且导致的牙齿染色更少；因此，它可能被推荐作为CHX的替代品使用。
