Lindsø Andersen Pernille, Villumsen Bente, Saunte Ditte Marie Lindhardt, Burgdorf Kristoffer Sølvsten, Didriksen Maria, Ostrowski Sisse Rye, Thørner Lise Wegner, Erikstrup Christian, Dinh Khoa Manh, Nielsen Kaspar René, Brodersen Thorsten, Bruun Mie Topholm, Banasik Karina, Hansen Thomas Folkmann, Pedersen Ole Birger, Jemec Gregor Borut
Department of Dermatology, Zealand University Hospital Roskilde, Sygehusvej 5, 4000, Roskilde, Denmark.
Department of Clinical Immunology, Zealand University Hospital, Køge, Denmark.
Arch Dermatol Res. 2023 Sep;315(7):1989-1994. doi: 10.1007/s00403-023-02570-0. Epub 2023 Mar 3.
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease associated with psychiatric comorbidity. Attention deficit hyperactivity disorder (ADHD) is a mental disorder associated with systemic and skin inflammation such as psoriasis and atopic dermatitis. Whether HS symptoms are associated with ADHD symptoms remains unexplored. Thus, the aim of this study was to explore the possible association between HS and ADHD. Participants in the Danish Blood Donor Study (DBDS) were included in this cross-sectional study during 2015-2017. The participants provided questionnaire data on screening items of HS, ADHD symptoms (ASRS-score), and depressive symptoms, smoking and body mass index (BMI). A logistic regression with HS symptoms as a binary outcome predicted by ADHD adjusted for age, sex, smoking, BMI, and depression was conducted to investigate the association between HS and ADHD. A total of 52,909 Danish blood donors were included in the study. Of these were 1004/52,909 (1.9%) considered participants with HS. Of the participants with HS, 74/996 (7.4%) screened positive of ADHD symptoms, while only 1786/51,129 (3.5%) of the participants without HS screened positive of ADHD. Adjusted for confounders, ADHD was positively associated with HS, odds ratio 1.85 (95% confidence interval: 1.43-2.37). Psychiatric comorbidity of HS is not limited to depression and anxiety. This study shows a positive association between HS and ADHD. Further research on the biological mechanisms behind this association is warranted.
化脓性汗腺炎（HS）是一种与精神疾病共病相关的慢性炎症性皮肤病。注意力缺陷多动障碍（ADHD）是一种与系统性和皮肤炎症（如银屑病和特应性皮炎）相关的精神障碍。HS症状是否与ADHD症状相关仍未得到探索。因此，本研究的目的是探讨HS与ADHD之间可能存在的关联。丹麦献血者研究（DBDS）的参与者在2015 - 2017年期间被纳入本横断面研究。参与者提供了关于HS筛查项目、ADHD症状（ASRS评分）、抑郁症状、吸烟情况和体重指数（BMI）的问卷数据。进行了一项以HS症状为二元结局、经年龄、性别、吸烟、BMI和抑郁调整后的ADHD预测的逻辑回归分析，以研究HS与ADHD之间的关联。共有52,909名丹麦献血者被纳入该研究。其中，1004/52,909（1.9%）被认为是患有HS的参与者。在患有HS的参与者中，74/996（7.4%）的ADHD症状筛查呈阳性，而在没有HS的参与者中，只有1786/51,129（3.5%）的ADHD筛查呈阳性。在对混杂因素进行调整后，ADHD与HS呈正相关，比值比为1.85（95%置信区间：1.43 - 2.37）。HS的精神疾病共病并不局限于抑郁和焦虑。本研究显示HS与ADHD之间存在正相关。有必要对这种关联背后的生物学机制进行进一步研究。
