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骨盆环损伤稳定后的手术部位感染:危险因素的回顾性分析和类似研究的荟萃分析。

Surgical site infections after stabilization of pelvic ring injuries: a retrospective analysis of risk factors and a meta-analysis of similar studies.

机构信息

Department of Orthopaedics and Traumatology, Faculty of Medicine of Charles University, and University Hospital, Pilsen, Czech Republic.

New Technologies for the Information Society, Faculty of Applied Sciences of University of West Bohemia, Alej Svobody 80, 304 60, Plzeň, Czech Republic.

出版信息

Int Orthop. 2023 May;47(5):1331-1344. doi: 10.1007/s00264-023-05719-8. Epub 2023 Mar 3.

Abstract

PURPOSE

Pelvic ring fractures requiring surgical stabilization are severe injuries. Surgical site infections occurring after stabilization of the pelvis are serious complications, requiring complex and multidisciplinary treatment.

METHODS

This is a retrospective observational study from a level I trauma centre. One hundred and ninety-two patients who underwent stabilization of closed pelvic ring injuries without signs of pathological fracture were selected for inclusion into the study. After excluding seven patients for having incomplete data, the final study group consisted of 185 patients (117 men and 68 women). Basic epidemiologic data and potential risk factors were recorded and analyzed by Cox regression, Kaplan-Meier curves, and risk ratios in 2 × 2 tables. Categorical variables were compared by Fisher exact tests and chi squared tests. Parametric variables were analyzed with Kruskal-Wallis tests with post hoc Wilcoxon tests.

RESULTS

Surgical site infections occurred in 13% of the study group (24 from 185). Eighteen infections occurred in men (15.4%) and six in women (8.8%). There were two significant risk factors in women: age over 50 years (p = 0.0232) and concomitant urogenital trauma (p = 0.0104). The common risk ratio for both these factors was 212.59 (8.78-5148.68), p = 0.0010. No significant risk factors were identified in men despite younger men having a higher incidence of infection (p = 0.1428).

CONCLUSION

Overall rate of infectious complications was higher than in the literature, but this might be caused by inclusion of all patients regardless of surgical strategy. Higher age in women and lower age in men were associated with higher infection rates. Concomitant urogenital trauma was a significant risk factor in women.

摘要

目的

需要手术稳定骨盆环骨折是严重的损伤。骨盆稳定后发生的手术部位感染是严重的并发症,需要复杂的多学科治疗。

方法

这是一项来自一级创伤中心的回顾性观察研究。选择了 192 名接受闭合性骨盆环损伤稳定治疗且无病理性骨折迹象的患者纳入研究。排除 7 例数据不完整的患者后,最终研究组包括 185 例患者(117 名男性和 68 名女性)。记录基本的流行病学数据和潜在的危险因素,并通过 Cox 回归、Kaplan-Meier 曲线和 2×2 表中的风险比进行分析。分类变量采用 Fisher 精确检验和卡方检验进行比较。参数变量采用 Kruskal-Wallis 检验和事后 Wilcoxon 检验进行分析。

结果

研究组中发生手术部位感染的比例为 13%(24 例/185 例)。18 例感染发生在男性(15.4%),6 例发生在女性(8.8%)。女性有两个显著的危险因素:年龄大于 50 岁(p=0.0232)和同时伴有泌尿生殖系统创伤(p=0.0104)。这两个因素的常见风险比均为 212.59(8.78-5148.68),p=0.0010。尽管年轻男性感染发生率较高,但男性中没有发现显著的危险因素(p=0.1428)。

结论

总的感染并发症发生率高于文献报道,但这可能是由于纳入了所有患者,而不论手术策略如何。女性年龄较大和男性年龄较小与较高的感染率相关。同时伴有泌尿生殖系统创伤是女性的一个显著危险因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a39/10079748/e2b17febfbbb/264_2023_5719_Fig1_HTML.jpg

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