Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt; Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo 11231, Egypt.
School of Biotechnology, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt.
Pathol Res Pract. 2023 Apr;244:154386. doi: 10.1016/j.prp.2023.154386. Epub 2023 Feb 28.
Cervical cancer (CC) is the primary cause of cancer deaths in underdeveloped countries. The persistence of infection with high-risk human papillomavirus (HPV) is a significant contributor to the development of CC. However, few women with morphologic HPV infection develop invasive illnesses, suggesting other mechanisms contribute to cervical carcinogenesis. MicroRNAs (miRNAs, miRs) are small chain nucleic acids that can regulate wide networks of cellular events. They can inhibit or degrade their target protein-encoding genes. They had the power to regulate CC's invasion, pathophysiology, angiogenesis, apoptosis, proliferation, and cell cycle phases. Further research is required, even though novel methods have been developed for employing miRNAs in the diagnosis, and treatment of CC. We'll go through some of the new findings about miRNAs and their function in CC below. The function of miRNAs in the development of CC and its treatment is one of these. Clinical uses of miRNAs in the analysis, prediction, and management of CC are also covered.
宫颈癌（CC）是发展中国家癌症死亡的主要原因。高危型人乳头瘤病毒（HPV）的持续感染是 CC 发展的一个重要因素。然而，很少有形态学 HPV 感染的女性会发展为侵袭性疾病，这表明其他机制也有助于宫颈癌的发生。微小 RNA（miRNA，miRs）是一种可以调节广泛的细胞事件网络的小分子核酸。它们可以抑制或降解其靶蛋白编码基因。它们有能力调节 CC 的侵袭、病理生理学、血管生成、细胞凋亡、增殖和细胞周期阶段。尽管已经开发了新的方法来利用 miRNA 诊断和治疗 CC，但仍需要进一步的研究。下面我们将介绍一些关于 miRNA 及其在 CC 中的功能的新发现。miRNA 在 CC 发展和治疗中的功能就是其中之一。miRNA 在 CC 的分析、预测和管理中的临床应用也包括在内。
