Department of Chemistry and Biochemistry, Old Dominion University, Norfolk, VA 23529, USA.
Biophys Chem. 2023 May;296:106983. doi: 10.1016/j.bpc.2023.106983. Epub 2023 Feb 26.
The transmembrane-electrostatically localized protons (TELP) theory can serve as a unified framework to explain experimental observations and elucidate bioenergetic systems including both delocalized and localized protonic coupling. With the TELP model as a unified framework, we can now better explain: the experimental results of Pohl's group (Zhang et al. 2012) as an effect of transient "excess protons" that can temporally form because of the difference between the fast protonic conduction in liquid water through the "hops and turns" mechanism and the relatively slow diffusion of chloride anions. This new understanding with the TELP theory agrees well with the independent analysis on the Pohl's lab group experiment results by Agmon and Gutman who also concluded that "the excess protons propagate as an advancing front".
跨膜静电定位质子（TELP）理论可以作为一个统一的框架来解释实验观察结果，并阐明包括非定域和定域质子偶联在内的生物能量系统。有了 TELP 模型作为一个统一的框架，我们现在可以更好地解释：Pohl 小组的实验结果（Zhang 等人，2012 年）是由于通过“跳跃和转弯”机制在液态水中快速质子传导与氯离子相对缓慢扩散之间的差异而暂时形成的瞬态“过剩质子”的影响。这种对 TELP 理论的新理解与 Agmon 和 Gutman 对 Pohl 实验室小组实验结果的独立分析一致，他们也得出结论，“过剩质子作为前沿传播”。
