Liu Guo-Dao, Wang Wei-Guo, Dai Chao, Cai Chun-Jie, Hu Qin
Department of Urology, Suzhou Science & Technology Town Hospital, Suzhou, Jiangsu, People's Republic of China.
Biol Trace Elem Res. 2023 Dec;201(12):5521-5528. doi: 10.1007/s12011-023-03613-3. Epub 2023 Mar 4.
Urinary incontinence (UI) is a major health burden to aging patients. The function of the trace element copper in male UI is unclear. To elaborate on the impact of serum copper levels on UI, we investigated the association between serum copper levels and UI using data from the National Health and Nutrition Examination Survey (NHANES), a cross-sectional survey of male participants aged 20 years old and older in the United States from 2011 to 2016. We performed weighted multivariable logistic and linear regression models to evaluate the association between serum copper levels and UI. Compared with serum copper levels in quartile 1 (Q1), serum copper levels in Q2 and Q3 were associated with stress urinary incontinence (SUI) after adjusting for all potential confounders (Q2, odds ratio [OR] = 0.292, 95% confidence interval [CI] = 0.093-0.920, P = 0.047; Q3, OR = 0.326, 95% CI = 0.113-0.937, P = 0.049). No significance was found between serum copper levels and other types of UI. Our findings revealed that the serum copper levels were inversely related to SUI in adult males. Race and education level might modulate this relationship. Further studies are warranted for validation.
尿失禁（UI）是老年患者的一项主要健康负担。微量元素铜在男性尿失禁中的作用尚不清楚。为了阐述血清铜水平对尿失禁的影响，我们利用美国国家健康与营养检查调查（NHANES）的数据，调查了血清铜水平与尿失禁之间的关联。NHANES是一项针对20岁及以上美国男性参与者的横断面调查，时间跨度为2011年至2016年。我们进行了加权多变量逻辑回归和线性回归模型，以评估血清铜水平与尿失禁之间的关联。与四分位数1（Q1）中的血清铜水平相比，在调整所有潜在混杂因素后，Q2和Q3中的血清铜水平与压力性尿失禁（SUI）相关（Q2，比值比[OR]=0.292，95%置信区间[CI]=0.093 - 0.920，P = 0.047；Q3，OR = 0.326，95% CI = 0.113 - 0.937，P = 0.049）。在血清铜水平与其他类型的尿失禁之间未发现显著关联。我们的研究结果表明，成年男性血清铜水平与压力性尿失禁呈负相关。种族和教育水平可能会调节这种关系。需要进一步研究进行验证。
