Department of Neurology, 36941Mie Prefectural General Medical Center, Yokkaichi, Japan.
Department of General and Laboratory Medicine, 36941Mie Prefectural General Medical Center, Yokkaichi, Japan.
Clin Appl Thromb Hemost. 2023 Jan-Dec;29:10760296231161591. doi: 10.1177/10760296231161591.
A few studies concerning hypercoagulable states have sufficiently been reported in patients with acute cerebral infarction (ACI), as ACI is generally considered to be caused by platelet activation. Clot waveform analyses (CWA) for activated partial thromboplastin time (APTT) and small amount of tissue factor FIX activation assay (sTF/FIXa) were examined in 108 patients with ACI, 61 patients without ACI, and 20 healthy volunteers. CWA-APTT and CWA-sTF/FIXa showed that the peak heights were significantly higher in ACI patients without anticoagulant therapy than in healthy volunteers. Absorbance exceeding 78.1 mm on the 1 DPH in the CWA-sTF/FIXa showed the highest odds ratio for ACI. The peak heights were significantly lower in the CWA-sTF/FIXa of ACI patients receiving argatroban therapy than in those of ACI patients without anticoagulant therapy. CWA can suggest a hypercoagulable state in ACI patients and may be useful for monitoring the need for anticoagulant therapy.
已有一些关于急性脑梗死（ACI）患者高凝状态的研究报告，因为 ACI 通常被认为是由血小板激活引起的。我们对 108 例 ACI 患者、61 例非 ACI 患者和 20 名健康志愿者进行了激活部分凝血活酶时间（APTT）的凝血波形分析（CWA）和少量组织因子 FIX 激活测定（sTF/FIXa）。CWA-APTT 和 CWA-sTF/FIXa 显示，未接受抗凝治疗的 ACI 患者的峰高明显高于健康志愿者。在 CWA-sTF/FIXa 中，1 DPH 上的吸光度超过 78.1 mm 时，发生 ACI 的优势比最高。接受阿加曲班治疗的 ACI 患者的 CWA-sTF/FIXa 峰高明显低于未接受抗凝治疗的 ACI 患者。CWA 可提示 ACI 患者存在高凝状态，可能有助于监测抗凝治疗的需要。
