Kang Fanhua, Yan Yuanliang, Liu Yuanhong, Liang Qiuju, Xu Zhijie, Zhu Wei, Thakur Abhimanyu
Department of Pathology, Xiangya Changde Hospital, Changde, Hunan, China.
Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Front Pharmacol. 2023 Feb 15;14:1093175. doi: 10.3389/fphar.2023.1093175. eCollection 2023.
Exosomes are nanoscale extracellular vesicles secreted by a variety of cells, affecting the physiological and pathological homeostasis. They carry various cargoes including proteins, lipids, DNA, and RNA and have emerged as critical mediators of intercellular communication. During cell-cell communication, they can internalize either by autologous or heterologous recipient cells, which activate different signaling pathways, facilitating malignant progression of cancer. Among different types of cargoes in exosomes, the endogenous non-coding RNAs, such as circular RNAs (or circRNAs), have gained tremendous attention for their high stability and concentration, playing promising functional roles in cancer chemotherapeutic response by regulating the targeted gene expression. In this review, we primarily described the emerging evidence demonstrating the important roles of circular RNAs derived from exosomes in the regulation of cancer-associated signaling pathways that were involved in cancer research and therapeutic interventions. Additionally, the relevant profiles of exosomal circRNAs and their biological implications have been discussed, which is under investigation for their potential effect on the control of cancer therapeutic resistance.
外泌体是由多种细胞分泌的纳米级细胞外囊泡，影响生理和病理稳态。它们携带包括蛋白质、脂质、DNA和RNA在内的各种物质，并已成为细胞间通讯的关键介质。在细胞间通讯过程中，它们可以被自体或异源受体细胞内化，激活不同的信号通路，促进癌症的恶性进展。在外泌体的不同类型物质中，内源性非编码RNA，如环状RNA（或circRNA），因其高稳定性和浓度而备受关注，通过调节靶基因表达在癌症化疗反应中发挥着有前景的功能作用。在这篇综述中，我们主要描述了新出现的证据，这些证据表明外泌体来源的环状RNA在调节与癌症相关的信号通路中发挥重要作用，这些信号通路参与癌症研究和治疗干预。此外，还讨论了外泌体circRNA的相关概况及其生物学意义，目前正在研究它们对控制癌症治疗耐药性的潜在影响。
